Al-Jafar Hassan A
Department of Hematology, Amiri Hospital, Kuwait City, Kuwait.
J Family Med Prim Care. 2017 Jan-Mar;6(1):69-72. doi: 10.4103/2249-4863.214986.
Anemia is a condition, in which the number of red blood cells (RBC) and the hemoglobin (Hb) is insufficient to meet the body's physiologic needs. Hypoferritinemia without anemia (HWA) could cause masked clinical manifestations as general weakness, easy fatigability, depressed mode, and hair loss but with normal complete blood count (CBC) parameters. HWA is deferent from iron deficiency anemia (IDA) because there is no reduction in the RBC, Hb, or any of the other parameters of the CBC. In HWA, the hypoferritinemia could be missed because serum ferritin not always requested by general practitioners.
A retrospective study conducted on 6993 patients of hypoferritinemia patients from our computerized database from 2010 to 2016. The parameters investigated to detect HWA disorder were serum ferritin, RBC, Hb, hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin.
HWA is found in 130 (0.018%) hypoferritinemia patients, in a ratio 1.7-1 females to male.
HWA is a masked hematology disorder which needs new nomenclature to distinguish it from IDA because they are two deferent disorders although both of them have low serum ferritin. HWA is not a latent IDA because it could happen in patients whom will not get anemia as in polycythemia patients on recurrent veinesection treatement.
贫血是一种红细胞（RBC）数量和血红蛋白（Hb）不足以满足身体生理需求的病症。无贫血性低铁蛋白血症（HWA）可能导致如全身无力、易疲劳、情绪低落和脱发等隐匿的临床表现，但全血细胞计数（CBC）参数正常。HWA与缺铁性贫血（IDA）不同，因为RBC、Hb或CBC的任何其他参数均无降低。在HWA中，低铁蛋白血症可能会被漏诊，因为全科医生并非总是要求检测血清铁蛋白。
对2010年至2016年来自我们计算机化数据库的6993例低铁蛋白血症患者进行回顾性研究。用于检测HWA病症的研究参数包括血清铁蛋白、RBC、Hb、血细胞比容、平均红细胞体积和平均红细胞血红蛋白。
在130例（0.018%）低铁蛋白血症患者中发现了HWA，女性与男性的比例为1.7比1。
HWA是一种隐匿的血液学病症，需要新的命名法将其与IDA区分开来，因为它们是两种不同的病症，尽管两者的血清铁蛋白均较低。HWA不是潜在的IDA，因为它可能发生在不会患贫血的患者身上，如接受反复静脉放血治疗的真性红细胞增多症患者。
