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慢性伤口愈合中的低频超声清创术:当前证据的系统评价

Low-Frequency Ultrasound Debridement in Chronic Wound Healing: A Systematic Review of Current Evidence.

作者信息

Chang Ying-Ju Ruby, Perry Julie, Cross Karen

机构信息

Department of Surgery, St Michael's Hospital, Toronto, Ontario, Canada.

出版信息

Plast Surg (Oakv). 2017 Feb;25(1):21-26. doi: 10.1177/2292550317693813. Epub 2017 Mar 21.

DOI:10.1177/2292550317693813
PMID:29026808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5626185/
Abstract

Chronic wounds are painful and debilitating to patients, pose a clinical challenge to physicians, and impose financial burden on the health-care system. New treatment options are therefore highly sought after. Ultrasound debridement is a promising technology that functions to disperse bacterial biofilms and stimulate wound healing. In this review, we focus on low-frequency ultrasound (20-60 kHz) and summarize the findings of 25 recent studies examining ultrasound efficacy. Ultrasound debridement appears to be most effective when used 3 times a week and has the potential to decrease exudate and slough, decrease patient pain, disperse biofilms, and increase healing in wounds of various etiology. Although current studies are generally of smaller size, the results are promising and we recommend the testing of low-frequency ultrasound therapy in clinical practice on a larger scale.

摘要

慢性伤口会给患者带来疼痛和功能障碍,给医生带来临床挑战,并给医疗保健系统造成经济负担。因此,人们迫切需要新的治疗方法。超声清创术是一项很有前景的技术,其作用是分散细菌生物膜并促进伤口愈合。在本综述中,我们聚焦于低频超声(20 - 60千赫),并总结了最近25项研究超声疗效的研究结果。超声清创术每周使用3次时似乎最为有效,并且有可能减少渗出物和腐肉,减轻患者疼痛,分散生物膜,并促进各种病因伤口的愈合。尽管目前的研究规模普遍较小,但结果很有前景,我们建议在临床实践中更大规模地测试低频超声治疗。

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本文引用的文献

1
A Pilot Study of Ultrasonically-assisted Treatment of Residual Burn Wounds .
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2
A novel in vitro wound biofilm model used to evaluate low-frequency ultrasonic-assisted wound debridement.一种用于评估低频超声辅助伤口清创的新型体外伤口生物膜模型。
J Wound Care. 2015 Feb;24(2):64, 66-9, 72. doi: 10.12968/jowc.2015.24.2.64.
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Low-frequency ultrasound for patients with lower leg ulcers due to chronic venous insufficiency: a report of two cases.低频超声治疗慢性静脉功能不全所致小腿溃疡患者:2例报告
Ostomy Wound Manage. 2014 Feb;60(2):52-61.
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Low-frequency (<100 kHz), low-intensity (<100 mW/cm(2)) ultrasound to treat venous ulcers: a human study and in vitro experiments.低频(<100 kHz)、低强度(<100 mW/cm(2))超声治疗静脉溃疡:人体研究和体外实验。
J Acoust Soc Am. 2013 Aug;134(2):1541-7. doi: 10.1121/1.4812875.
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A pilot study evaluating non-contact low-frequency ultrasound and underlying molecular mechanism on diabetic foot ulcers.一项评估非接触式低频超声及其对糖尿病足溃疡潜在分子机制的初步研究。
Int Wound J. 2014 Dec;11(6):586-93. doi: 10.1111/iwj.12005. Epub 2012 Nov 19.
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The microbiome in wound repair and tissue fibrosis.微生物组在伤口修复和组织纤维化中的作用。
J Pathol. 2013 Jan;229(2):323-31. doi: 10.1002/path.4118. Epub 2012 Nov 29.
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A prospective pilot study of ultrasound therapy effectiveness in refractory venous leg ulcers.超声治疗在难治性静脉性腿部溃疡中的前瞻性初步研究。
Int Wound J. 2012 Oct;9(5):570-8. doi: 10.1111/j.1742-481X.2011.00921.x. Epub 2012 Feb 1.
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Low-frequency ultrasound (20-40 kHz) as an adjunctive therapy for chronic wound healing: a systematic review of the literature and meta-analysis of eight randomized controlled trials.低频超声(20 - 40千赫)作为慢性伤口愈合的辅助治疗:文献系统综述及八项随机对照试验的荟萃分析
Int J Low Extrem Wounds. 2011 Dec;10(4):190-9. doi: 10.1177/1534734611424648.
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Effects of low-frequency ultrasound on microcirculation in venous leg ulcers.低频超声对下肢静脉溃疡微循环的影响。
Indian J Dermatol. 2011 Mar;56(2):174-9. doi: 10.4103/0019-5154.80412.
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Noncontact low-frequency ultrasound therapy in the treatment of chronic wounds: a meta-analysis.非接触式低频超声疗法治疗慢性创面的Meta 分析。
Wound Repair Regen. 2011 Jul-Aug;19(4):475-80. doi: 10.1111/j.1524-475X.2011.00701.x. Epub 2011 Jun 7.