Zhang Nenling, Shen Xiangchun, Jiang Xiaofei, Cai Jiazhong, Shen Xiaoling, Hu Yingjie, Qiu Samuel X
Pharmacy College of Guizhou Medical University, University Town, Gui'an New District, Guiyang, 550025, China.
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou, 510650, China.
J Nat Med. 2018 Jan;72(1):304-309. doi: 10.1007/s11418-017-1138-x. Epub 2017 Oct 12.
Two new stilbenoid dimers, cajanstilbenoids A (1) and B (2), were isolated from the leaves of Cajanus cajan. Planar structures of these compounds were verified by NMR (1D and 2D) and high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Absolute configurations were assigned by comparing experimental and calculated electronic CD values. The cytotoxicity of 1 and 2 against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7), and human lung cancer (A549) cells were evaluated in vitro. Compound 1 showed strong cytotoxicity against all the tested cell lines (IC values: 2.14-2.56 µM), whereas compound 2 showed strong toxicity only against HepG2 (IC value: 5.99 µM) and A549 cells (IC value: 6.18 µM).
从木豆叶中分离出两种新的二苯乙烯类二聚体，木豆芪类化合物A（1）和B（2）。这些化合物的平面结构通过核磁共振（一维和二维）和高分辨率电喷雾电离质谱（HR-ESI-MS）进行了验证。通过比较实验和计算的电子圆二色值确定了绝对构型。在体外评估了化合物1和2对人肝癌（HepG2）、人乳腺腺癌（MCF-7）和人肺癌（A549）细胞的细胞毒性。化合物1对所有测试细胞系均表现出强细胞毒性（IC值：2.14 - 2.56 μM），而化合物2仅对HepG2（IC值：5.99 μM）和A549细胞（IC值：6.18 μM）表现出强毒性。
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