来自施氏血桐的细胞毒性香叶基芪类化合物。

Cytotoxic geranyl stilbenes from Macaranga schweinfurthii.

作者信息

Beutler J A, Shoemaker R H, Johnson T, Boyd M R

机构信息

Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.

出版信息

J Nat Prod. 1998 Dec;61(12):1509-12. doi: 10.1021/np980208m.

DOI:10.1021/np980208m

PMID:9868152

Abstract

Three novel geranyl stilbenes, schweinfurthins A, B, and C (1, 2, and 3), were isolated from the Cameroonian plant Macaranga schweinfurthii (Euphorbiaceae) and their structures determined by NMR and mass spectral methods. The cytotoxicity profile of the schweinfurthins tested in the NCI 60-cell screen was similar to that of the stelletins and cephalostatins, suggesting that these structurally diverse natural products may share similar mechanisms of cytotoxicity.

摘要

从喀麦隆植物施氏血桐（大戟科）中分离出三种新型香叶基芪类化合物，施氏血桐素A、B和C（1、2和3），并通过核磁共振和质谱方法确定了它们的结构。在NCI 60细胞筛选中测试的施氏血桐素的细胞毒性谱与海星毒素和头霉素的相似，这表明这些结构多样的天然产物可能具有相似的细胞毒性机制。