Tang Daiyuan, Gao Wei, Yuan Yajiang, Guo Lingling, Mei Xifan
The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China.
Nanoscale Res Lett. 2017 Oct 12;12(1):565. doi: 10.1186/s11671-017-2332-1.
Nanoprobes are rapidly becoming potentially transformative tools on disease diagnostics for a wide range of in vivo computed tomography (CT) imaging. Compared with conventional molecular-scale contrast agents, nanoparticles (NPs) promise improved abilities for in vivo detection. In this study, novel polyethylene glycol (PEG)-functionalized Au nanoparticles with star shape (AuNS@PEG) with strong X-ray mass absorption coefficient were synthesized as CT imaging contrast agents. Experimental results revealed that AuNS@PEG nanoparticles are well constructed with ultrasmall sizes, effective metabolisability, high computed tomography value, and outstanding biocompatibility. In vivo imaging also showed that the obtained AuNS@PEG nanoparticles can be efficiently used in CT-enhanced imaging. Therefore, the synthesized contrast agent AuNS@PEG nanoparticles as a great potential candidate can be widely used for CT imaging.
纳米探针正迅速成为用于多种体内计算机断层扫描（CT）成像的疾病诊断中具有潜在变革性的工具。与传统的分子尺度造影剂相比，纳米颗粒（NPs）有望提高体内检测能力。在本研究中，合成了具有强X射线质量吸收系数的新型聚乙二醇（PEG）功能化星形金纳米颗粒（AuNS@PEG）作为CT成像造影剂。实验结果表明，AuNS@PEG纳米颗粒结构良好，尺寸超小，具有有效的代谢能力、高计算机断层扫描值和出色的生物相容性。体内成像还表明，所获得的AuNS@PEG纳米颗粒可有效地用于CT增强成像。因此，合成的造影剂AuNS@PEG纳米颗粒作为极具潜力的候选者可广泛用于CT成像。
