Gao Yan, Kang Jian, Lei Zhen, Li Yankun, Mei Xifan, Wang Guannan
The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China.
College of Pharmacy, Jinzhou Medical University, Jinzhou, 121001, China.
Nanoscale Res Lett. 2020 Mar 4;15(1):53. doi: 10.1186/s11671-020-3286-2.
In recent years, contrast agents have been widely used in imaging technology to improve quality. Nanoparticles have better in vivo detection capability than conventional molecular scale contrast agents. In this study, a new type of Au nanocages@PEG nanoparticles (AuNC@PEGs) with a strong X-ray absorption coefficient was synthesized as a contrast agent for computed tomography (CT) scan imaging. Results showed that AuNC@PEGs had good aqueous dispensation, low cytotoxicity, and strong X-ray absorption ability. Furthermore, in vivo studies have shown that the synthesized AuNC@PEGs have an evident contrast enhancement, long circulation time in the blood, and negligible toxicity in vivo. Therefore, the synthesized functionalized AuNC@PEGs in this study have great potential for clinical application in CT scan imaging.
近年来，造影剂已广泛应用于成像技术以提高成像质量。纳米颗粒比传统分子尺度的造影剂具有更好的体内检测能力。在本研究中，合成了一种具有强X射线吸收系数的新型金纳米笼@聚乙二醇纳米颗粒（AuNC@PEGs）作为计算机断层扫描（CT）成像的造影剂。结果表明，AuNC@PEGs具有良好的水分散性、低细胞毒性和强X射线吸收能力。此外，体内研究表明，合成的AuNC@PEGs具有明显的造影增强效果、在血液中的长循环时间以及体内可忽略不计的毒性。因此，本研究中合成的功能化AuNC@PEGs在CT成像的临床应用中具有巨大潜力。
