Li Du, Zhang Yongxing, Wen Shihui, Song Yang, Tang Yueqin, Zhu Xiaoyue, Shen Mingwu, Mignani Serge, Majoral Jean-Pierre, Zhao Qinghua, Shi Xiangyang
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, People's Republic of China.
J Mater Chem B. 2016 Jun 21;4(23):4216-4226. doi: 10.1039/c6tb00773b. Epub 2016 May 27.
The advancement of biocompatible nanoplatforms with dual functionalities of diagnosis and therapeutics has been strongly demanded in biomedicine in recent years. In this work, we report the synthesis and characterization of polydopamine (pD)-coated gold nanostars (Au NSs) for computed tomography (CT) imaging and enhanced photothermal therapy (PTT) of tumors. Au NSs were firstly formed via a seed-mediated growth method and then stabilized with thiolated polyethyleneimine (PEI-SH), followed by deposition of pD on their surface. The formed pD-coated Au NSs (Au-PEI@pD NSs) were well characterized. We show that the Au-PEI@pD NSs are able to convert the absorbed near-infrared laser light into heat, and have strong X-ray attenuation properties. Due to the co-existence of Au NSs and pD, the light to heat conversion efficiency of the NSs can be significantly enhanced. These very interesting properties allow them to be used as a powerful theranostic nanoplatform for efficient CT imaging and enhanced phtotothermal therapy of cancer cells in vitro and the xenografted tumor model in vivo. Due to their easy functionalization nature enabled by the coated pD shell, the developed pD-coated Au NSs may be used as a versatile nanoplatform for targeted CT imaging and PTT of different types of cancers.
近年来，生物医学领域对具有诊断和治疗双重功能的生物相容性纳米平台的需求强烈。在这项工作中，我们报告了用于计算机断层扫描（CT）成像和增强肿瘤光热疗法（PTT）的聚多巴胺（pD）包覆金纳米星（Au NSs）的合成与表征。Au NSs首先通过种子介导生长法形成，然后用硫醇化聚乙烯亚胺（PEI-SH）稳定，随后在其表面沉积pD。对形成的pD包覆Au NSs（Au-PEI@pD NSs）进行了充分表征。我们表明，Au-PEI@pD NSs能够将吸收的近红外激光转化为热量，并具有很强的X射线衰减特性。由于Au NSs和pD的共存，纳米星的光热转换效率可以显著提高。这些非常有趣的特性使其能够用作强大的诊疗纳米平台，用于体外癌细胞的高效CT成像和增强光热疗法以及体内异种移植肿瘤模型。由于包覆的pD壳使其易于功能化，所开发的pD包覆Au NSs可作为用于不同类型癌症的靶向CT成像和PTT的通用纳米平台。
