The theoretical basis of neuronal coding, associated with short-term degradation in synaptic transmission, is a matter of debate in the literature. In fact, electrophysiological signals are commonly characterized as inversely proportional to stimulus intensity. Among theoretical descriptions of this phenomenon, models based on 1/f-dependency are employed to investigate the biophysical properties of short-term synaptic depression. In this work, we formulate a model based on a paradigmatic q-differential equation to obtain a generalized formalism useful for investigation of nonextensivity in this specific type of synaptic plasticity. Our analysis reveals nonextensivity in data from electrophysiological recordings and also a statistical crossover in neurotransmission. In particular, statistical transitions provide additional support to the hypothesis of heterogeneous release probability of neurotransmitters. On the other hand, the simple vesicle model agrees with data only at low-frequency stimulations. Thus, the present work presents a method to demonstrate that short-term depression is not only governed by random mechanisms but also by nonextensive behavior. Our findings also conciliate morphological and electrophysiological investigations into a coherent biophysical scenario.