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波兰先天性风疹综合征发病率的计算。

Calculation of the frequency of congenital rubella syndrome in Poland.

作者信息

Imbs D, Sandow D, Denkmann N, Kańtoch M

机构信息

Department of Virology, National Institute of Hygiene, Warsaw, Poland.

出版信息

Acta Virol. 1988 May;32(3):235-42.

PMID:2902771
Abstract

The annual number and incidence of congenital rubella syndrome (CRS) in Poland was evaluated by means of a methematical model and on the basis of serological studies. In its principles this model describes the infectious kinetics of rubella by the formula y = 1--e-at, where "y" is the rate of immune persons, "a" is a parameter representing the transfer of susceptibles to immunes and "t" is age. The calculated incidence of congenital rubella syndrome resulted in average values of 0.15 to 0.38%, i.e. 15 to 38 CRS cases among 100,000 children born to mothers primarily infected by rubella virus during the first trimester of pregnancy.

摘要

通过数学模型并基于血清学研究对波兰先天性风疹综合征(CRS)的年度病例数和发病率进行了评估。该模型的原理是用公式y = 1 - e-at来描述风疹的感染动力学,其中“y”是免疫人群的比例,“a”是代表易感者转变为免疫者的参数,“t”是年龄。计算得出的先天性风疹综合征发病率平均值为0.15%至0.38%,即在孕期头三个月主要感染风疹病毒的母亲所生的100,000名儿童中,有15至38例CRS病例。

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