• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Restriction fragment length polymorphism and activation of c-Ha-ras gene in urothelial cancer.

作者信息

Ishikawa J, Maeda S, Kamidono S, Sugiyama T

机构信息

Department of Pathology, Kobe University School of Medicine, Japan.

出版信息

Anticancer Res. 1988 Sep-Oct;8(5A):915-24.

PMID:2902823
Abstract

The human c-Ha-ras gene shows restriction length polymorphism (RFLP) due to the variable tandem repetition (VTR) of DNA sequences in the 3'-flanking region. It was suggested that RFLP of the c-Ha-ras gene may be useful in detecting individuals at risk of cancer. In vitro studies showed transcriptional enhancer and promoter activities in the VTR region. In some human tumors, the loss of one c-Ha-ras allele is observed. We discuss here the possible role of VTR and allelic deletion of the c-Ha-ras allele in primary human cancers in relation to c-Ha-ras expression, and the usefulness of c-Ha-ras RFLP in the risk assessment of urothelial cancer.

摘要

相似文献

1
Restriction fragment length polymorphism and activation of c-Ha-ras gene in urothelial cancer.
Anticancer Res. 1988 Sep-Oct;8(5A):915-24.
2
c-Ha-ras BamHI RFLP in human urothelial tumors and point mutations in hot codons.人尿路上皮肿瘤中的c-Ha-ras BamHI限制性片段长度多态性及热点密码子中的点突变
Neoplasma. 1993;40(4):223-7.
3
A new RFLP in intron 1 of the human c-Ha-ras1 gene and its close relationship with the variable tandem repeats in the region 3' to the gene.
Oncogene. 1990 Jul;5(7):1049-53.
4
Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing.H-ras 基因突变在膀胱癌中并不常见：通过单链构象多态性分析、设计的限制性片段长度多态性和直接测序得以证实。
Cancer Res. 1993 Jan 1;53(1):133-9.
5
c-Ha-ras-1 polymorphism in human breast carcinomas: evidence for a normal distribution of alleles.人类乳腺癌中c-Ha-ras-1基因多态性：等位基因呈正态分布的证据
Oncogene Res. 1988 Feb;2(3):245-50.
6
Human restriction fragment length polymorphisms and cancer risk assessment.
J Cell Biochem. 1986;30(4):319-29. doi: 10.1002/jcb.240300405.
7
[Urothelial cancers. Cytogenetic and molecular biology principles].[尿路上皮癌。细胞遗传学和分子生物学原理]
Urologe A. 1994 Mar;33(2):122-7.
8
[Frequency and rearrangements of alleles of proto-oncogene c-Ha-ras-1 and their association with development of various malignant tumors in man].[原癌基因c-Ha-ras-1等位基因的频率、重排及其与人各种恶性肿瘤发生的关系]
Genetika. 1990 Mar;26(3):531-40.
9
Study of the c-Ha-ras-1 locus polymorphism in an Italian population with high incidence of gastric cancer.对胃癌高发的意大利人群中c-Ha-ras-1基因座多态性的研究。
Mol Biol Med. 1988 Dec;5(3):145-53.
10
Hypomethylation of CCGG sites in the 3' region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer.H-ras原癌基因3'区域CCGG位点的低甲基化很常见，且与非小细胞肺癌中的H-ras等位基因缺失相关。
Cancer Res. 1994 Mar 1;54(5):1145-8.

引用本文的文献

1
Restriction fragment length polymorphism of the L-myc gene in oral cancer patients.口腔癌患者中L-myc基因的限制性片段长度多态性
Br J Cancer. 1990 Apr;61(4):530-3. doi: 10.1038/bjc.1990.119.
2
Distribution of Ha-ras alleles in patients with colorectal cancer and Crohn's disease.结直肠癌和克罗恩病患者中Ha-ras等位基因的分布
Gut. 1991 Dec;32(12):1508-13. doi: 10.1136/gut.32.12.1508.