Criborn C O, Muren A, Ahlenius S, Hillegaart V
Naval Medicine Division, National Defence Research Institute, Stockholm, Sweden.
Aviat Space Environ Med. 1988 Aug;59(8):723-7.
Two ergot derivatives, lisuride and quinpirole, were examined for their ability to antagonize hyperbaric oxygen-induced (5 ATA O2) convulsions in mice. Significant protection was obtained by lisuride (25-400 micrograms.kg-1, i.p.) and quinpirole (100-200 micrograms.kg-1, i.p.). The efficacy was found to be about 50% of the protection obtained by diazepam (4 mg.kg-1, i.p.). Both lisuride and quinpirole significantly reduced rectal temperature at all doses administered. In separate experiments, at normal atmospheric conditions, all drugs to some extent reduced estimated respiratory minute volume. Taking these effects into account, lisuride is considerably more active as an anticonvulsant than quinpirole.
研究了两种麦角衍生物，利苏瑞肽和喹吡罗拮抗小鼠高压氧诱导（5个绝对大气压氧气）惊厥的能力。利苏瑞肽（25 - 400微克·千克⁻¹，腹腔注射）和喹吡罗（100 - 200微克·千克⁻¹，腹腔注射）可提供显著保护。发现其疗效约为地西泮（4毫克·千克⁻¹，腹腔注射）所提供保护的50%。利苏瑞肽和喹吡罗在所有给药剂量下均显著降低直肠温度。在单独实验中，在正常大气条件下，所有药物在一定程度上均降低了估计的每分钟呼吸量。考虑到这些作用，利苏瑞肽作为抗惊厥药比喹吡罗活性更强。
