Horowski R
Naunyn Schmiedebergs Arch Pharmacol. 1979 Mar;306(2):147-51. doi: 10.1007/BF00498984.
The semisynthetic ergot derivative lisuride induced dose- and time-dependent hypothermia in rats placed in a cold environment (+4 degrees C). As regards dosage, lisuride was more than 100 times more effective in this test model than bromocriptine. The effect of both drugs could be reduced by pretreatment with the dopamine antagonist haloperidol, which indicated a dopaminergic action of both drugs. In contrast, the hypothermic effect of lisuride could not be impaired by pretreatment with sulpiride, whilst the effects of bromocriptine were clearly antagonized by this drug. This results could be explained by a different affinity of these drugs to the same receptors, or, more likely, by a different mechanism of action by which lisuride and bromocriptine activate dopaminergic systems.
半合成麦角衍生物利苏瑞在置于寒冷环境（+4摄氏度）的大鼠中可诱导剂量和时间依赖性体温过低。在该测试模型中，就剂量而言，利苏瑞比溴隐亭有效100多倍。两种药物的作用均可通过多巴胺拮抗剂氟哌啶醇预处理而减弱，这表明两种药物均具有多巴胺能作用。相比之下，舒必利预处理不会削弱利苏瑞的体温过低作用，而溴隐亭的作用则会被该药物明显拮抗。这些结果可以通过这些药物对相同受体的不同亲和力来解释，或者更有可能是通过利苏瑞和溴隐亭激活多巴胺能系统的不同作用机制来解释。
