Arunjaroensuk Sirida, Panmekiate Soontra, Pimkhaokham Atiphan
Int J Oral Maxillofac Implants. 2018 January/February;33(1):206–216. doi: 10.11607/jomi.5492. Epub 2017 Oct 13.
This randomized controlled clinical trial compared the stability of augmented bone between a synthetic resorbable membrane and a collagen resorbable membrane with guided bone regeneration (GBR) simultaneous with dental implant placement in the esthetic zone in terms of facial bone thickness.
A total of 60 dental implants from patients requiring implant placement with simultaneous GBR in the esthetic zone were equally allocated to the test group or control group by block randomization. Biphasic calcium phosphate ceramic bone was used in combination with either a polylactic acid (PLA) membrane (test group, 30 implants) or a resorbable collagen membrane (control group, 30 implants). Cone beam computed tomographic (CBCT) images were used to assess the facial bone thickness postimplantation and then 6 months later at four levels: implant platform and 2 mm, 4 mm, and 6 mm apical to the implant shoulder.
All implants were osseointegrated, and no implant loss was found during this study. Facial bone was detected in all cases; however, the thickness of the facial bone was reduced at the 6-month follow-up in both groups. The percentage of facial bone thickness reduction was 34.30%, 27.94%, 24.25%, and 19.81% in the test group and 34.80%, 24.06%, 19.52%, and 20.45% in the control group at the level of the implant platform and at 2 mm, 4 mm, and 6 mm apical to the implant shoulder, respectively. Nevertheless, there was no statistically significant difference between the groups (P > .05).
A synthetic resorbable membrane revealed an amount of stable augmented bone similar to that of a collagen resorbable membrane.
本随机对照临床试验比较了在美学区域同时进行引导骨再生（GBR）和牙种植体植入时，合成可吸收膜与胶原可吸收膜在增加骨量方面的稳定性，具体指标为面部骨厚度。
总共60颗来自美学区域需要同时进行GBR植入种植体的患者的牙齿，通过区组随机化法平均分配到试验组或对照组。双相磷酸钙陶瓷骨与聚乳酸（PLA）膜（试验组，30颗种植体）或可吸收胶原膜（对照组，30颗种植体）联合使用。采用锥形束计算机断层扫描（CBCT）图像评估植入后以及6个月后的面部骨厚度，评估水平为种植体平台以及种植体肩部根尖方向2mm、4mm和6mm处。
所有种植体均实现骨整合，本研究期间未发现种植体丢失。所有病例均检测到面部骨；然而，两组在6个月随访时面部骨厚度均降低。在种植体平台以及种植体肩部根尖方向2mm、4mm和6mm处，试验组面部骨厚度降低百分比分别为34.30%、27.94%、24.25%和19.81%，对照组分别为34.80%、24.06%、19.52%和20.45%。然而，两组之间无统计学显著差异（P > 0.05）。
合成可吸收膜显示出与胶原可吸收膜相似的稳定增加骨量。
