Tierney Savanna, Woods Steven Paul, Verduzco Marizela, Beltran Jessica, Massman Paul J, Hasbun Rodrigo
Department of Psychology, University of Houston, USA.
Department of Psychiatry, University of California San Diego, USA.
Arch Clin Neuropsychol. 2018 Jun 1;33(4):406-416. doi: 10.1093/arclin/acx083.
HIV-associated neurocognitive disorders (HAND) have historically been characterized as a subcortical condition that does not affect semantic memory; however, recent evidence suggests that the cortical regions that support semantic memory may be affected in HIV.
The current study examined the effects of HAND on semantic memory in 85 HIV+ individuals with HAND, 193 HIV+ individuals without HAND, and 181 HIV- individuals who completed the Boston Naming Test (BNT) and the Famous Faces subtest of the Kauffman Adolescent and Adult Intelligence Test (KAIT-FF).
Linear regressions revealed a significant adverse effect of HAND on total scores on the BNT and the KAIT-FF (all ps < .01). Analyses of BNT errors showed that individuals with HAND committed more semantically related errors as compared to the other two study groups (all ps < .05). However, there were no group differences in rates of visually based errors, which are more commonly observed in traditional subcortical diseases (all ps > .10).
Results indicate that HAND may impose adverse effects on individuals' object naming and identification abilities suggestive of mild semantic deficits that parallel traditional cortical diseases such as Alzheimer's disease.
与HIV相关的神经认知障碍（HAND）在历史上一直被描述为一种不影响语义记忆的皮质下疾病；然而，最近的证据表明，支持语义记忆的皮质区域在HIV患者中可能会受到影响。
本研究调查了HAND对85名患有HAND的HIV阳性个体、193名未患HAND的HIV阳性个体以及181名HIV阴性个体语义记忆的影响，这些个体均完成了波士顿命名测试（BNT）和考夫曼青少年及成人智力量表（KAIT-FF）中的名人面孔子测试。
线性回归显示，HAND对BNT和KAIT-FF的总分有显著的不利影响（所有p值均<.01）。对BNT错误的分析表明，与其他两个研究组相比，患有HAND的个体出现了更多语义相关的错误（所有p值均<.05）。然而，在基于视觉的错误发生率上，各组之间没有差异，而这种错误在传统的皮质下疾病中更常见（所有p值均>.10）。
结果表明，HAND可能会对个体的物体命名和识别能力产生不利影响，提示存在与阿尔茨海默病等传统皮质疾病类似的轻度语义缺陷。
