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用于常规和均整滤过(FFF)调强放疗(IMRT)治疗前验证的新型二维探测器阵列的特性描述和临床评估。

Characterization and clinical evaluation of a novel 2D detector array for conventional and flattening filter free (FFF) IMRT pre-treatment verification.

机构信息

Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Germany.

Radioterapia, Policlinico di Modena, Via del Pozzo 71, 41124 Modena, Italy.

出版信息

Z Med Phys. 2018 Apr;28(2):134-141. doi: 10.1016/j.zemedi.2017.08.003. Epub 2017 Oct 11.

Abstract

BACKGROUND AND PURPOSE

The novel MatriXX (IBA Dosimetry, Germany) detector is a new 2D ionization chamber detector array designed for patient specific IMRT-plan verification including flattening-filter-free (FFF) beams. This study provides a detailed analysis of the characterization and clinical evaluation of the new detector array.

MATERIAL AND METHODS

The verification of the MatriXX was subdivided into (i) physical dosimetric tests including dose linearity, dose rate dependency and output factor measurements and (ii) patient specific IMRT pre-treatment plan verifications. The MatriXX measurements were compared to the calculated dose distribution of a commissioned treatment planning system by gamma index and dose difference evaluations for 18 IMRT-sequences. All IMRT-sequences were measured with original gantry angles and with collapsing all beams to 0° gantry angle to exclude the influence of the detector's angle dependency.

RESULTS

The MatriXX was found to be linear and dose rate independent for all investigated modalities (deviations ≤0.6%). Furthermore, the output measurements of the MatriXX were in very good agreement to reference measurements (deviations ≤1.8%). For the clinical evaluation an average pixel passing rate for γ of (98.5±1.5)% was achieved when applying a gantry angle correction. Also, with collapsing all beams to 0° gantry angle an excellent agreement to the calculated dose distribution was observed (γ=(99.1±1.1)%).

CONCLUSIONS

The MatriXX fulfills all physical requirements in terms of dosimetric accuracy. Furthermore, the evaluation of the IMRT-plan measurements showed that the detector particularly together with the gantry angle correction is a reliable device for IMRT-plan verification including FFF.

摘要

背景与目的

新型 MatriXX(IBA Dosimetry,德国)探测器是一种新型 2D 电离室探测器阵列,专为特定于患者的调强放疗计划验证设计,包括无均整过滤器(FFF)射束。本研究对新型探测器阵列的特性和临床评估进行了详细分析。

材料与方法

MatriXX 的验证分为(i)物理剂量学测试,包括剂量线性度、剂量率依赖性和输出因子测量,以及(ii)特定于患者的调强放疗前计划验证。通过伽马指数和剂量差异评估,将 MatriXX 的测量结果与经过委托的治疗计划系统的计算剂量分布进行比较,共对 18 个调强放疗序列进行了评估。所有调强放疗序列均使用原始机架角度进行测量,并将所有射束折叠到 0°机架角度,以排除探测器角度依赖性的影响。

结果

MatriXX 在所有研究模式下均表现出线性和剂量率独立性(偏差≤0.6%)。此外,MatriXX 的输出测量与参考测量非常吻合(偏差≤1.8%)。在临床评估中,当应用机架角度校正时,γ的平均像素通过率为(98.5±1.5)%。此外,当将所有射束折叠到 0°机架角度时,观察到与计算剂量分布非常吻合(γ=(99.1±1.1)%)。

结论

MatriXX 在剂量学准确性方面满足所有物理要求。此外,调强放疗计划测量的评估表明,该探测器特别是与机架角度校正一起,是包括 FFF 在内的调强放疗计划验证的可靠设备。

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