Zhang Qiang, Wang Xiaobiao, Wang Xiaojun, Zhou Changjun
Key Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, Dalian University, Dalian, 116622, China; School of Computer Science and Technology, Dalian University of Technology, Dalian, 116024, China.
Key Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, Dalian University, Dalian, 116622, China.
Comput Biol Chem. 2017 Dec;71:274-279. doi: 10.1016/j.compbiolchem.2017.09.011. Epub 2017 Sep 28.
In computation biology, DNA strand displacement technology is used to simulate the computation process and has shown strong computing ability. Most researchers use it to solve logic problems, but it is only rarely used in probabilistic reasoning. To process probabilistic reasoning, a conditional probability derivation model and total probability model based on DNA strand displacement were established in this paper. The models were assessed through the game "read your mind." It has been shown to enable the application of probabilistic reasoning in genetic diagnosis.
在计算生物学中，DNA链置换技术用于模拟计算过程，并已显示出强大的计算能力。大多数研究人员用它来解决逻辑问题，但它在概率推理中很少被使用。为了处理概率推理，本文建立了基于DNA链置换的条件概率推导模型和全概率模型。这些模型通过“猜你所想”游戏进行评估。结果表明，该模型能够使概率推理应用于基因诊断。
