Rozengurt Roman, Shtoots Limor, Sheriff Aviv, Sadka Ofir, Levy Daniel A
Sagol Department of Neurobiology, University of Haifa, Haifa 3498838, Israel.
Baruch Ivcher School of Psychology, Interdisciplinary Center Herzliya, Herzliya 4610101, Israel.
Neurobiol Learn Mem. 2017 Nov;145:165-171. doi: 10.1016/j.nlm.2017.10.005. Epub 2017 Oct 10.
Consolidation of newly formed memories is readily disrupted, but can it be enhanced? Given the prominent role of hippocampal theta oscillations in memory formation and retrieval, we hypothesized that upregulating theta power during early stages of consolidation might benefit memory stability and persistence. We used EEG neurofeedback to enable participants to selectively increase theta power in their EEG spectra following episodic memory encoding, while other participants engaged in low beta-focused neurofeedback or passively viewed a neutral nature movie. Free recall assessments immediately following the interventions, 24h later and 7d later all indicated benefit to memory of theta neurofeedback, relative to low beta neurofeedback or passive movie-viewing control conditions. The degree of benefit to memory was correlated with the extent of theta power modulation, but not with other spectral changes. Theta enhancement may provide optimal conditions for stabilization of new hippocampus-dependent memories.
新形成记忆的巩固很容易被破坏，但它能否得到增强呢？鉴于海马体θ振荡在记忆形成和提取中所起的重要作用，我们推测在巩固的早期阶段上调θ功率可能有益于记忆的稳定性和持久性。我们使用脑电图神经反馈，使参与者在情景记忆编码后能够选择性地增加其脑电图频谱中的θ功率，而其他参与者则进行以低β波为重点的神经反馈或被动观看一部中性的自然电影。干预后立即、24小时后和7天后的自由回忆评估均表明，相对于低β波神经反馈或被动观看电影的对照条件，θ神经反馈对记忆有益。对记忆的有益程度与θ功率调制的程度相关，但与其他频谱变化无关。θ增强可能为新的海马体依赖性记忆的稳定提供最佳条件。
