Busto U, Fornazzari L, Naranjo C A
Pharmacy Department, Addiction Research Foundation, Toronto, Ontario, Canada.
J Clin Psychopharmacol. 1988 Oct;8(5):359-62.
The presence of protracted tinnitus after discontinuation of long-term therapeutic doses of diazepam (less than or equal to 30 mg/day) is described in three patients. In one of these patients, the association of the tinnitus appearance with the drug discontinuation was documented in a double-blind, randomized, crossover single case study. Objective confirmation of drug use or of abstinence was performed by obtaining plasma benzodiazepine concentrations. The findings provide further documentation that sensory disturbances of short- and long-term duration are among the most distinctive clinical features of the benzodiazepine withdrawal syndrome.
三名患者出现了在停用长期治疗剂量的地西泮（小于或等于30毫克/天）后持续存在耳鸣的情况。在其中一名患者中，耳鸣出现与药物停用之间的关联在一项双盲、随机、交叉单病例研究中得到了记录。通过检测血浆苯二氮䓬浓度对药物使用或戒断进行客观确认。这些发现进一步证明，短期和长期的感觉障碍是苯二氮䓬戒断综合征最显著的临床特征之一。
