循环脂肪酸与饮酒量的关系：一项针对 60 岁男性和女性队列的横断面研究结果。

Circulating fatty acids in relation to alcohol consumption: Cross-sectional results from a cohort of 60-year-old men and women.

机构信息

Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 171 77 Stockholm, Sweden.

Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Box 609, 751 25 Uppsala, Sweden.

出版信息

Clin Nutr. 2018 Dec;37(6 Pt A):2001-2010. doi: 10.1016/j.clnu.2017.09.007. Epub 2017 Sep 25.

DOI:10.1016/j.clnu.2017.09.007

PMID:29032841

Abstract

BACKGROUND & AIMS: Alcohol consumption is considered to affect circulating fatty acids (FAs) but knowledge about specific associations is limited. We aimed to assess the relation between alcohol consumption and serum FAs in 60-year-old Swedish men and women.

METHODS

In a random sample of 1917 men and 2058 women residing in Stockholm county, cross-sectional associations between different categories of alcohol consumption and FAs were assessed using linear regression; β coefficients with 95% confidence interval (CI) were calculated. Self-reported alcohol consumption was categorized as none, low (≤9.9 g/day) (reference), moderate (10-29.9 g/day) and high (≥30 g/day). Moderate alcohol consumption was further subdivided into consumption of beer, wine, liquor and their combinations. Thirteen serum cholesterol ester FAs were measured by gas chromatography and individual FAs were expressed as percentage of total FAs.

RESULTS

Increasing alcohol consumption was associated to linear increase of saturated myristic acid, monounsaturated FAs and n-6 polyunsaturated (PUFA) arachidonic acid, whereas linear decrease was noted for saturated pentadecanoic acid and for n-6 PUFA linoleic acid. With non-linear associations, increasing alcohol consumption also associated to decreased saturated stearic acid, n-6 PUFA dihomo-gamma-linolenic acid, and n-3 PUFA docosahexaenoic acid and increased saturated palmitic acid, n-6 PUFA gamma-linolenic acid and n-3 PUFA eicosapentaenoic acid. Among types of beverages, wine consumption was associated with n-6 PUFA arachidonic acid (β 0.59; 95% CI: 0.30;0.88) and the n-3 PUFAs eicosapentaenoic acid (β 0.54; 95% CI: 0.30;0.78), and docosahexaenoic acid (β 0.06; 95% CI: 0.00;0.12).

CONCLUSIONS

These findings may give important basis for further investigations to better understand biological mechanisms behind the dose-dependent associations between alcohol consumption and health outcomes observed in many previous studies.

摘要

背景与目的

饮酒被认为会影响循环脂肪酸（FAs），但具体关联的相关知识有限。我们旨在评估瑞典 60 岁男性和女性的饮酒与血清 FAs 之间的关系。

方法

在斯德哥尔摩县的随机样本中，有 1917 名男性和 2058 名女性，使用线性回归评估不同类别的饮酒与 FAs 之间的横断面关联；计算了 95%置信区间（CI）的β系数。自我报告的饮酒量分为无、低（≤9.9 g/天）（参考）、中（10-29.9 g/天）和高（≥30 g/天）。中度饮酒进一步细分为啤酒、葡萄酒、白酒及其组合的摄入量。通过气相色谱法测量了 13 种血清胆固醇酯 FAs，并用总 FAs 的百分比表示个体 FAs。

结果

随着饮酒量的增加，饱和肉豆蔻酸、单不饱和脂肪酸和 n-6 多不饱和脂肪酸（PUFA）花生四烯酸呈线性增加，而饱和十五烷酸和 n-6 PUFA 亚油酸则呈线性下降。随着非线性关联，饮酒量的增加也与饱和硬脂酸、n-6 PUFA 二高-γ-亚麻酸和 n-3 PUFA 二十二碳六烯酸的减少以及饱和棕榈酸、n-6 PUFA γ-亚麻酸和 n-3 PUFA 二十碳五烯酸的增加有关。在饮料类型中，葡萄酒摄入与 n-6 PUFA 花生四烯酸（β 0.59；95%CI：0.30；0.88）和 n-3 PUFAs 二十碳五烯酸（β 0.54；95%CI：0.30；0.78）和二十二碳六烯酸（β 0.06；95%CI：0.00；0.12）相关。