Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Gorgas Memorial Institute for Health Studies, Panama City, Panama.
BMC Cardiovasc Disord. 2019 Feb 4;19(1):34. doi: 10.1186/s12872-019-1014-6.
The aim of this study is to investigate if IL8 levels were associated with incident cardiovascular (CV) events (CVE) and mortality (all-cause, CV, and cancer) in a cohort of 60 years old men and women from Stockholm (60YO).
The 60YO comprises 4232 participants; baseline period: 1997-1999. The cohort is matched annually to population registries to record deaths and incident CVE. Serum IL8 was measured in 4011 participants and categorized in quartiles. Cox proportional hazard models were used to estimate the CVE and mortality risk, expressed as hazard ratios (HR) with 95% confidence intervals (CI). Potential confounding was addressed by adjusting for traditional CV risk factors (CVE estimates) and by sex, life style habits, metabolic factors (mortality estimates). Laplace regression was used to calculate the difference in time until a certain percentage of the cohort died according to IL8 levels.
During 16.5 years follow up, 522 incident CVE were recorded and 647 study participants died. IL8 was not associated with CVE risk (IL8 Q4 vs Q1, HR of 0.95; 95% CI 0.75-1.22). Compared to Q1, IL8 Q4 was associated with all-cause mortality (adjusted HR 1.28; 95% CI 1.02-1.63). No association was observed with CV and cancer related mortality in the fully adjusted model. Participants with IL8 above the median died of any cause ≈1.3 years before the 15% of the population had died.
Elevated IL8 levels were not associated with CVE risk and CV mortality, but were associated with an increased risk of all-cause mortality regardless of the underlying cause.
本研究旨在探讨白细胞介素 8（IL8）水平是否与斯德哥尔摩 60 岁人群（60YO）心血管事件（CVE）和死亡率（全因、心血管和癌症）的发生相关。
60YO 队列包含 4232 名参与者，基线期为 1997-1999 年。该队列每年与人口登记处匹配，以记录死亡和新发 CVE。4011 名参与者检测了血清 IL8，并分为四等分。使用 Cox 比例风险模型估计 CVE 和死亡率风险，用危险比（HR）和 95%置信区间（CI）表示。通过调整传统心血管危险因素（CVE 估计值）和性别、生活方式习惯、代谢因素（死亡率估计值）来解决潜在混杂因素。拉普拉斯回归用于计算根据 IL8 水平，队列中一定比例的人死亡所需时间的差异。
在 16.5 年的随访期间，记录了 522 例新发 CVE，有 647 名研究参与者死亡。IL8 与 CVE 风险无关（IL8 Q4 与 Q1，HR 为 0.95；95%CI 为 0.75-1.22）。与 Q1 相比，IL8 Q4 与全因死亡率相关（调整 HR 为 1.28；95%CI 为 1.02-1.63）。在完全调整模型中，未观察到与心血管和癌症相关死亡率的关联。IL8 水平高于中位数的参与者因任何原因死亡的时间比人群中 15%的人死亡的时间提前了约 1.3 年。
升高的 IL8 水平与 CVE 风险和心血管死亡率无关，但与全因死亡率的增加相关，而与潜在病因无关。
