Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Vaccine. 2017 Nov 1;35(46):6264-6268. doi: 10.1016/j.vaccine.2017.09.069. Epub 2017 Oct 9.
Streptococcus pneumoniae (pneumococcus) is responsible for serious pediatric respiratory infections, and kills close to one million children under the age of five each year. Unfortunately, the Prevnar-13 vaccine (PCV-13) that is used to protect children from the serious consequences of pneumococcus infections is not always successful. Given that vitamin A deficiency (VAD) is known to affect children in both developed and developing countries, we asked if VAD could be responsible, at least in part, for PCV-13 vaccine failures. In a mouse model for VAD, we found that PCV-13 failed to elicit binding and neutralizing antibody activities. Unlike vaccinated, vitamin-replete animals, vaccinated VAD animals were not protected from lethal pneumococcus infections. Results suggest that children with VAD may be susceptible to serious pneumococcal infections even after having received the PCV-13 vaccine.
肺炎链球菌（肺炎球菌）可导致严重的小儿呼吸道感染，每年导致近 100 万名 5 岁以下儿童死亡。不幸的是，用于预防肺炎球菌感染严重后果的Prevnar-13 疫苗（PCV-13）并非总是有效。鉴于维生素 A 缺乏症（VAD）已知会影响发达国家和发展中国家的儿童，我们想知道 VAD 是否至少部分导致了 PCV-13 疫苗失效。在 VAD 小鼠模型中，我们发现 PCV-13 未能引起结合和中和抗体活性。与接种疫苗但维生素充足的动物不同，接种疫苗但 VAD 的动物不能免受致死性肺炎球菌感染的保护。结果表明，即使儿童已经接种了 PCV-13 疫苗，他们仍可能易患严重的肺炎球菌感染。
