Sharma Pramod Kumar, Misra Arup Kumar, Chugh Ankita, Chugh Vinay Kumar, Gonnade Nitesh, Singh Surjit
Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Department of Dental Surgery, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Indian J Pharmacol. 2017 May-Jun;49(3):257-259. doi: 10.4103/ijp.IJP_57_17.
Gingival overgrowth (GO) is one of the common findings in clinical practice. There could be several causes including drugs associated with the GO. Carbamazepine (CBZ) and amlodipine are the drugs which are infrequently documented as a cause in inducing the gingival hyperplasia. Certain drugs in the body fluid might limit the population of plaque bacteria and alter their metabolism that in turn induce the inflammatory mediators and also activate the genetic and biochemical factors responsible for gingival fibroblast growth. Drug-induced GO is a side effect with a multifactorial etiology that seems to orchestrate the interaction between drugs and fibroblasts in the gingiva. We describe a case of trigeminal neuralgia with hypertension treated with multiple drugs including amlodipine and CBZ. Although amlodipine is known to be infrequently associated with GO, an association of CBZ with GO is even rarer. Causality analysis on the World Health Organization Uppsala Monitoring Centre's scale indicates a probable association with offending drugs.
牙龈增生（GO）是临床实践中常见的表现之一。其病因可能有多种，包括与牙龈增生相关的药物。卡马西平（CBZ）和氨氯地平是较少被记录为导致牙龈增生原因的药物。体液中的某些药物可能会限制菌斑细菌数量并改变其代谢，进而诱导炎症介质产生，还会激活负责牙龈成纤维细胞生长的遗传和生化因子。药物性牙龈增生是一种具有多因素病因的副作用，似乎是药物与牙龈成纤维细胞之间相互作用的结果。我们描述了一例三叉神经痛合并高血压患者，使用了包括氨氯地平和CBZ在内的多种药物进行治疗。尽管已知氨氯地平很少与牙龈增生相关，而CBZ与牙龈增生的关联更为罕见。根据世界卫生组织乌普萨拉监测中心的标准进行因果关系分析，提示与致病药物可能存在关联。
