Marshall R I, Bartold P M
Department of Dentistry, University of Queensland, Brisbane, Australia.
Oral Dis. 1998 Jun;4(2):130-51. doi: 10.1111/j.1601-0825.1998.tb00269.x.
A number of idiopathic, pathological and pharmacological reactions may result in an overgrowth of the gingiva. This review concentrates on those overgrowths associated with various pharmacological agents. The pharmaco-kinetics and side effects of each drug associated with gingival overgrowth are discussed along with the clinical and histological features and treatment. By examining the possible pathogeneses for these overgrowths we propose a unifying hypothesis for the causation based around inhibition of apoptosis and decreased collagenase activity modulated by cytoplasmic calcium.
许多特发性、病理性和药理学反应可能导致牙龈过度生长。本综述聚焦于与各种药物制剂相关的牙龈过度生长。文中讨论了每种与牙龈过度生长相关药物的药代动力学和副作用，以及临床和组织学特征与治疗方法。通过研究这些过度生长的可能发病机制，我们围绕细胞凋亡抑制和细胞质钙调节的胶原酶活性降低提出了一个关于病因的统一假说。
