Department of Internal Medicine, University of Maryland Medical Centre Midtown Campus, Baltimore, USA.
All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Curr Drug Saf. 2022;17(3):281-283. doi: 10.2174/1574886316666211122125215.
DIGO or drug-induced gingival overgrowth occurs as a side effect of certain drugs. Until now, the etiology of drug-induced gingival overgrowth is not clearly understood. Among the calcium channel blockers, nifedipine has been shown to be most frequently associated with drug-induced gingival hyperplasia. Amlodipine is a comparatively newer calcium channel blocker that with a longer duration of action and lesser side effects as compared to nifedipine. There are only certain case reports of amlodipine-induced gum hyperplasia.
We report a case of amlodipine-induced gum hyperplasia in a 66-year-old hypertensive patient taking amlodipine at a dose of 5 mg once a day. There was significant regression of gum hypertrophy after substitution of amlodipine by Losartan.
Amlodipine is one of the commonly prescribed antihypertensive drugs, and gingival hyperplasia is one overlooked side effect in patients taking amlodipine. Awareness of this potential side effect of amlodipine may be helpful to reduce the anxiety of patients and the cost of diagnostic procedures.
药物性牙龈增生是某些药物的副作用之一。到目前为止，药物性牙龈增生的病因尚不清楚。在钙通道阻滞剂中，硝苯地平最常与药物性牙龈增生有关。氨氯地平是一种相对较新的钙通道阻滞剂，与硝苯地平相比，其作用持续时间更长，副作用更小。只有少数氨氯地平引起的牙龈增生的病例报告。
我们报告了一例 66 岁高血压患者服用氨氯地平（剂量为 5 毫克，每日一次）引起的牙龈增生。氨氯地平换用氯沙坦后，牙龈肥大明显消退。
氨氯地平是一种常用的降压药物，而牙龈增生是服用氨氯地平患者被忽视的副作用之一。了解氨氯地平的这种潜在副作用可能有助于减轻患者的焦虑和诊断程序的成本。
