Gutierrez-Loli Renzo, Orrego Miguel A, Sevillano-Quispe Oscar G, Herrera-Arrasco Luis, Guerra-Giraldez Cristina
Neurocysticercosis Lab, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
Front Microbiol. 2017 Sep 29;8:1905. doi: 10.3389/fmicb.2017.01905. eCollection 2017.
MicroRNAs (miRNAs) are short, endogenous, non-coding, single-stranded RNAs involved in post-transcriptional gene regulation. Although, several miRNAs have been identified in parasitic helminths, there is little information about their identification and function in . Furthermore, the impact of miRNAs in neurocysticercosis, the brain infection caused by larvae of is still unknown. During chronic infection, may activate numerous mechanisms aimed to modulate host immune responses. Helminthic miRNAs might also have effects on host mRNA expression and thus play an important role regulating host-parasite interactions. Also, the diagnosis of this disease is difficult and it usually requires neuroimaging and confirmatory serology. Since miRNAs are stable when released, they can be detected in body fluids and therefore have potential to diagnose infection, determine parasite burden, and ascertain effectiveness of treatment or disease progression, for instance. This review discusses the potential roles of miRNAs in infection, including regulation of host-parasite relationships and their eventual use as diagnostic or disease biomarkers. Additionally, we summarize the bioinformatics resources available for identification of miRNAs and prediction of their targets.
微小RNA（miRNA）是一类短的、内源性的、非编码单链RNA，参与转录后基因调控。尽管在寄生性蠕虫中已鉴定出多种miRNA，但关于它们在[此处原文缺失具体物种]中的鉴定和功能的信息却很少。此外，miRNA在由[此处原文缺失具体物种]幼虫引起的脑囊尾蚴病（一种脑部感染）中的影响仍然未知。在慢性感染期间，[此处原文缺失具体物种]可能会激活许多旨在调节宿主免疫反应的机制。蠕虫的miRNA也可能对宿主mRNA表达产生影响，从而在调节宿主 - 寄生虫相互作用中发挥重要作用。此外，这种疾病的诊断困难，通常需要神经影像学检查和确诊血清学检测。由于miRNA释放后很稳定，它们可以在体液中被检测到，因此有可能用于诊断感染、确定寄生虫负荷以及确定治疗效果或疾病进展等。本综述讨论了miRNA在[此处原文缺失具体物种]感染中的潜在作用，包括调节宿主 - 寄生虫关系以及它们最终作为诊断或疾病生物标志物的用途。此外，我们总结了可用于鉴定[此处原文缺失具体物种]miRNA及其靶标的生物信息学资源。
