Zheng Yadong
State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, CAAS, Lanzhou 730046, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.
Infect Genet Evol. 2017 Jul;51:98-100. doi: 10.1016/j.meegid.2017.03.023. Epub 2017 Mar 22.
Taenia ovis is a tapeworm that is mainly transmitted between dogs and sheep or goats and has an adverse effect on sheep industry. miRNAs are short regulatory non-coding RNAs, involved in parasite development and growth as well as parasite infection. The miRNA profile of T. ovis remains to be established. Herein, 33 known miRNAs belonging to 23 different families were identified in T. ovis metacestodes using deep sequencing approach. Of them, expression of some miRNAs such as tov-miR-10 and -let-7 was absolutely predominant. Moreover, comparative analysis revealed the presence of a miR-71/2b/2c cluster in T. ovis, which was also completely conserved in other 6 cestodes. The study provides rich data for further understandings of T. ovis biology.
绵羊带绦虫是一种主要在狗与绵羊或山羊之间传播的绦虫，对绵羊养殖业有不利影响。微小RNA（miRNA）是短的调节性非编码RNA，参与寄生虫的发育、生长以及寄生虫感染过程。绵羊带绦虫的miRNA图谱仍有待确定。在此，利用深度测序方法在绵羊带绦虫的中绦期幼虫中鉴定出了属于23个不同家族的33种已知miRNA。其中，一些miRNA如tov-miR-10和-let-7的表达绝对占主导地位。此外，比较分析显示绵羊带绦虫中存在miR-71/2b/2c簇，该簇在其他6种绦虫中也完全保守。该研究为进一步了解绵羊带绦虫生物学提供了丰富的数据。
