Yaneva-Sirakova Teodora, Traykov Latchezar, Petrova Julia, Vassilev Dobrin
Department of Internal Medicine, Cardiology Clinic, Sofia Medical University, Sofia, Bulgaria.
Department of Neurology, Neurology Clinic, Sofia Medical University, Sofia, Bulgaria.
Dement Geriatr Cogn Dis Extra. 2017 Aug 29;7(2):274-282. doi: 10.1159/000479365. eCollection 2017 May-Aug.
We compared the role of central blood pressure (BP), ambulatory BP monitoring (ABPM), home-measured BP (HMBP) and office BP measurement as risk markers for the development of mild cognitive impairment (MCI).
70 hypertensive patients on combination medical therapy were studied. Their mean age was 64.97 ± 8.88 years. Eighteen (25.71%) were males and 52 (74.28%) females. All of the patients underwent full physical examination, laboratory screening, echocardiography, and office, ambulatory, home and central BP measurement. The neuropsychological tests used were: Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). SPSS 19 was used for the statistical analysis with a level of significance of 0.05.
The mean central pulse pressure values of patients with MCI were significantly ( = 0.016) higher than those of the patients without MCI. There was a weak negative correlation between central pulse pressure and the results from the MoCA and MMSE ( = -0.283, = 0.017 and = -0.241, = 0.044, respectively). There was a correlation between ABPM and MCI as well as between HMBP and MCI.
The correlation of central BP with target organ damage (MCI) is as good as for the other types of measurements of BP (home and ambulatory). Office BP seems to be the poorest marker for the assessment of target organ damage.
我们比较了中心血压（BP）、动态血压监测（ABPM）、家庭自测血压（HMBP）和诊室血压测量作为轻度认知障碍（MCI）发生风险标志物的作用。
对70例接受联合药物治疗的高血压患者进行了研究。他们的平均年龄为64.97±8.88岁。其中18例（25.71%）为男性，52例（74.28%）为女性。所有患者均接受了全面的体格检查、实验室筛查、超声心动图检查以及诊室、动态、家庭和中心血压测量。所使用的神经心理学测试包括：简易精神状态检查表（MMSE）和蒙特利尔认知评估量表（MoCA）。使用SPSS 19进行统计分析，显著性水平为0.05。
MCI患者的平均中心脉压值显著高于（ = 0.016）无MCI的患者。中心脉压与MoCA和MMSE结果之间存在弱负相关（分别为 = -0.283， = 0.017和 = -0.241， = 0.044）。ABPM与MCI之间以及HMBP与MCI之间均存在相关性。
中心血压与靶器官损害（MCI）的相关性与其他类型的血压测量（家庭和动态）相当。诊室血压似乎是评估靶器官损害最差的标志物。
