Pande Paritosh, Monroy Guillermo L, Nolan Ryan M, Shelton Ryan L, Boppart Stephen A
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
J Sens. 2016;2016. doi: 10.1155/2016/8154809.
Hand-held optical coherence tomography (OCT) imaging probes offer flexibility to image sites that are otherwise challenging to access. While the majority of hand-held imaging probes utilize galvanometer- or MEMS-scanning mirrors to transversely scan the imaging beam, these probes are commonly limited to lateral fields-of-view (FOV) of only a few millimeters. The use of a freehand manually scanned probe can significantly increase the lateral FOV. However, using the traditional fixed-rate triggering scheme for data acquisition in a manually scanned probe results in imaging artifacts due to variations in the scan velocity of the imaging probe. These artifacts result in a structurally inaccurate image of the sample. In this paper, we present a sensor-based manual scanning technique for OCT imaging, where real-time feedback from an optical motion sensor is used to trigger data acquisition. This technique is able to circumvent the problem of motion artifacts during manual scanning by adaptively altering the trigger rate based on the instantaneous scan velocity, enabling OCT imaging over a large lateral FOV. The feasibility of the proposed technique is demonstrated by imaging several biological and nonbiological samples.
手持式光学相干断层扫描（OCT）成像探头为那些难以触及的部位成像提供了灵活性。虽然大多数手持式成像探头利用振镜或微机电系统（MEMS）扫描镜对成像光束进行横向扫描，但这些探头的横向视野（FOV）通常仅局限于几毫米。使用徒手手动扫描探头可显著增加横向视野。然而，在手动扫描探头中使用传统的固定速率触发方案进行数据采集时，由于成像探头扫描速度的变化会导致成像伪影。这些伪影会造成样本结构图像不准确。在本文中，我们提出了一种基于传感器的OCT成像手动扫描技术 在该技术中，利用光学运动传感器的实时反馈来触发数据采集。通过基于瞬时扫描速度自适应地改变触发速率，该技术能够规避手动扫描过程中的运动伪影问题，从而实现大横向视野的OCT成像。通过对多个生物和非生物样本进行成像，证明了所提技术的可行性。
