Palermo Sara, Morese Rosalba, Zibetti Maurizio, Dematteis Francesca, Sirgiovanni Stefano, Stanziano Mario, Valentini Maria Consuelo, Lopiano Leonardo
Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, Italy.
Department of Psychology, University of Turin, Via Verdi 10, 10123 Turin, Italy.
J Adv Res. 2017 Nov;8(6):713-716. doi: 10.1016/j.jare.2017.09.004. Epub 2017 Sep 21.
This report illustrates a Parkinson's disease (PD) patient with impulse-control disorder (ICD) and selective impairment in response-inhibition abilities as revealed by the performance in a functional magnetic resonance imaging (fMRI) anterior cingulate cortex - sensitive go-nogo task. In line with hypothesis on the role of response-inhibition disabilities in the arising of impulsivity in PD, the patient completely failed the go-nogo task. Moreover, fMRI acquisition revealed absent task-sensitive activity in the anterior cingulate cortex, medial prefrontal, and orbitofrontal cortices for the contrast nogo versus go, which signifying that a hypo-function of this network could be associated with ICD. A fronto-striatal and cingulo-frontal dysfunction may reflect impairment in metacognitive-executive abilities (such as response-inhibition, action monitoring, and error awareness) and promote compulsive repetition of behavior. Response-inhibition tasks may be useful in PD post-diagnostic phase, to better identify individuals at risk of developing ICD with dopaminergic medication.
本报告展示了一名帕金森病（PD）患者，该患者患有冲动控制障碍（ICD），并且在功能磁共振成像（fMRI）前扣带回皮质敏感的停止信号任务中的表现显示出反应抑制能力的选择性受损。与关于反应抑制障碍在PD冲动性产生中的作用的假设一致，该患者在停止信号任务中完全失败。此外，fMRI采集显示，在对比无信号与有信号时，前扣带回皮质、内侧前额叶和眶额叶皮质缺乏任务敏感活动，这表明该网络功能低下可能与ICD有关。额纹状体和扣带回额叶功能障碍可能反映元认知执行能力（如反应抑制、动作监测和错误意识）受损，并促进行为的强迫性重复。反应抑制任务在PD诊断后阶段可能有用，以更好地识别有因多巴胺能药物而发展为ICD风险的个体。
