Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Department of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Neurol Sci. 2021 Jul;42(7):2937-2946. doi: 10.1007/s10072-020-04917-1. Epub 2020 Nov 24.
Patients with akinetic-rigid Parkinson's disease (AR-PD) are more prone to cognitive decline and depressive symptoms than tremor-dominant PD (TD-PD) patients. The right fronto-insular cortex (rFIC), as a key node of salience network, plays a critical role in the switching between central executive network and default mode network. In this study, we explored the functional connectivity mode of rFIC with triple-brain networks, namely default mode network, salience network, and central executive network, in two motor subtypes of PD.
We recruited 44 PD patients (including the TD-PD group and AR-PD group) and 18 age-matched healthy controls (HCs). We performed functional connectivity (FC) analysis of resting-state functional MRI.
Compared with TD-PD, decreased FC were found in the right insular cortex and bilateral anterior cingulate gyrus in AR-PD. Compared with HCs, decreased FC in the bilateral insula, the anterior cingulate gyrus, the precentral gyrus, and the right medial frontal gyrus were found; therein, the FC value of rFIC-precentral gyrus was positively correlated with the Unified Parkinson's Disease Rating Scale-II score in AR-PD (p = 0.0482, r = 0.4162). While TD-PD showed decreased FC in the left insula as well as bilateral anterior cingulate gyrus when compared with HCs, and the FC value of the rFIC-left insula was positively correlated with its Hamilton Depression Rating Scale score (p = 0.02, r = 0.50).
The functional connectivity mode of rFIC in AR-PD differed from that in TD-PD. The decreased rFIC FC with the other nodes of salience network might be a potential indicator for AR-PD patients prone to develop cognitive decline and depressive symptoms.
与震颤为主型帕金森病（TD-PD）患者相比，运动不能-强直型帕金森病（AR-PD）患者更易发生认知功能下降和抑郁症状。右侧额岛盖部皮质（rFIC）作为突显网络的关键节点，在中央执行网络和默认模式网络之间的切换中起着至关重要的作用。在这项研究中，我们探讨了 rFIC 与三重脑网络（即默认模式网络、突显网络和中央执行网络）的功能连接模式，在两种 PD 运动亚型中。
我们招募了 44 名 PD 患者（包括 TD-PD 组和 AR-PD 组）和 18 名年龄匹配的健康对照者（HCs）。我们进行了静息态功能磁共振的功能连接（FC）分析。
与 TD-PD 相比，AR-PD 右侧岛叶和双侧前扣带回的 FC 降低。与 HCs 相比，AR-PD 双侧岛叶、前扣带回、中央前回和右侧额内侧回的 FC 降低，其中 rFIC-中央前回的 FC 值与 AR-PD 的统一帕金森病评定量表-Ⅱ评分呈正相关（p = 0.0482，r = 0.4162）。而与 HCs 相比，TD-PD 左侧岛叶和双侧前扣带回的 FC 降低，rFIC-左侧岛叶的 FC 值与汉密尔顿抑郁评定量表评分呈正相关（p = 0.02，r = 0.50）。
AR-PD 中 rFIC 的功能连接模式与 TD-PD 不同。rFIC 与突显网络其他节点的 FC 降低可能是 AR-PD 患者易发生认知功能下降和抑郁症状的潜在指标。
