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Nutr Cancer. 2017 Apr;69(3):464-469. doi: 10.1080/01635581.2017.1285406. Epub 2017 Feb 17.
2
Nutritional Support in Esophagogastric Cancers.食管癌和胃癌的营养支持
Surg Oncol Clin N Am. 2017 Apr;26(2):325-333. doi: 10.1016/j.soc.2016.10.003. Epub 2017 Feb 9.
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Physical and Nutritional Prehabilitation in Older Patients With Colorectal Carcinoma: A Systematic Review.老年结直肠癌患者的身体和营养预康复:一项系统综述
J Geriatr Phys Ther. 2018 Oct/Dec;41(4):236-244. doi: 10.1519/JPT.0000000000000125.
4
Never too old to fight cancer? What do we know about colorectal cancer in the elderly?
Colorectal Dis. 2017 Mar;19(3):223. doi: 10.1111/codi.13610.
5
Impact of the prognostic nutritional index on the recovery and long-term oncologic outcome of patients with colorectal cancer.预后营养指数对结直肠癌患者恢复及长期肿瘤学结局的影响。
J Cancer Res Clin Oncol. 2017 Jul;143(7):1235-1242. doi: 10.1007/s00432-017-2366-x. Epub 2017 Feb 27.
6
Use of a Comprehensive Geriatric Assessment to Predict Short-Term Postoperative Outcome in Elderly Patients With Colorectal Cancer.使用综合老年评估来预测老年结直肠癌患者术后短期结局
Ann Coloproctol. 2016 Oct;32(5):161-169. doi: 10.3393/ac.2016.32.5.161. Epub 2016 Oct 31.
7
Physical performance measures for predicting outcome in cancer patients: a systematic review.预测癌症患者预后的身体机能测量指标:一项系统综述
Acta Oncol. 2016 Dec;55(12):1386-1391. doi: 10.1080/0284186X.2016.1219047. Epub 2016 Oct 8.
8
Why Can't Surgeons Treat Older Patients the Same as Younger Patients?为什么外科医生不能像治疗年轻患者那样治疗老年患者?
Ann Surg Oncol. 2016 Dec;23(13):4123-4125. doi: 10.1245/s10434-016-5459-x. Epub 2016 Jul 25.
9
Delivering tailored surgery to older cancer patients: Preoperative geriatric assessment domains and screening tools - A systematic review of systematic reviews.为老年癌症患者提供个性化手术:术前老年评估领域和筛查工具——系统评价的系统综述
Eur J Surg Oncol. 2017 Jan;43(1):1-14. doi: 10.1016/j.ejso.2016.06.003. Epub 2016 Jun 21.
10
Fall-risk prediction in older adults with cancer: an unmet need.老年癌症患者的跌倒风险预测:一项未满足的需求。
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接受胃肠道恶性肿瘤根治性肿瘤切除术的老年患者不良结局的危险因素。

Risk Factors for Adverse Outcome for Elderly Patients undergoing Curative Oncological Resection for Gastrointestinal Malignancies.

作者信息

Lim Yukai K, Jackson Christopher, Dauway Emilia L, Richter Konrad Klaus

机构信息

Southern District Health Board, Invercargill, New Zealand.

University of Otago, Dunedin, New Zealand.

出版信息

Visc Med. 2017 Aug;33(4):254-261. doi: 10.1159/000475938. Epub 2017 Aug 10.

DOI:10.1159/000475938
PMID:29034253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5624239/
Abstract

BACKGROUND

The incidence of gastrointestinal cancer increases with age, with approximately 20% of these cases in people over 80 years of age. Due to pre-existing comorbidities, this onco-geriatric population often presents diagnostic and therapeutic challenges.

METHODS

A systematic review of articles on PubMed was performed to determine the predictive ability of screening tools and their components regarding the occurrence of adverse outcomes in elderly onco-surgical patients with gastrointestinal malignancies.

RESULTS

Surgical procedures in this patient cohort, particularly complex resections, may result in increased morbidity and mortality. The decision to treat an elderly patient with curative intent requires sound clinical judgment based on knowledge, consideration of objective parameters, and experience. These patients could potentially be optimized for surgery with the improvement of nutritional and overall performance status as well as with stabilizing comorbidities.

CONCLUSION

Various geriatric assessment and screening tools have been developed to identify risk factors to assist the surgeon and the interdisciplinary team in treatment planning, including the Frailty Assessment Score, Timed Up and Go test, nutritional status, and Activities of Daily Living test. It is important to emphasize that transparent and open communication between the treating surgeon and the patient is crucial in that the patient fully understands the implications of the treatment plan.

摘要

背景

胃肠道癌的发病率随年龄增长而增加,80岁以上人群中约20%的病例属于此类。由于存在合并症,这一老年肿瘤患者群体常常面临诊断和治疗方面的挑战。

方法

对PubMed上的文章进行系统综述,以确定筛查工具及其组成部分对老年胃肠道恶性肿瘤外科手术患者不良结局发生情况的预测能力。

结果

该患者队列中的外科手术,尤其是复杂切除术,可能会导致发病率和死亡率上升。决定对老年患者进行根治性治疗需要基于知识、对客观参数的考量以及经验做出合理的临床判断。通过改善营养和整体身体状况以及稳定合并症,这些患者有可能在手术方面达到最佳状态。

结论

已经开发了各种老年评估和筛查工具来识别风险因素,以协助外科医生和多学科团队进行治疗规划,包括衰弱评估评分、计时起立行走测试、营养状况和日常生活活动测试。必须强调的是,主治外科医生与患者之间透明且开放的沟通至关重要,因为患者要充分理解治疗计划的影响。