Wageningen University, Human and Animal Physiology, Wageningen, The Netherlands.
Nutricia Research, Utrecht, Netherlands.
Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700315. Epub 2017 Dec 11.
Metabolic programming can occur not only in the perinatal period, but also post-weaning. This study aims to assess whether fructose, in comparison to glucose, in the post-weaning diet programs body weight, adiposity, glucose tolerance, metabolic flexibility, and health at adult age.
Three-week-old male and female C57BL6/JRccHsd mice are given an intervention diet with 32 energy percent (en%) glucose or fructose for only 3 weeks. Next, all animals are switched to the same 40 en% high fat diet for 9 weeks. Neither body weight nor adiposity differs significantly between the animals fed with glucose or fructose diets at any point during the study in both sexes. Glucose tolerance in adulthood is not affected by the post-weaning diet, nor are activity, energy expenditure, and metabolic flexibility, as measured by indirect calorimetry. At the end of the study, only in females fasting serum insulin levels and HOMA-IR index are lower in post-weaning fructose versus glucose diet (p = 0.02), without differences in pancreatic β-cell mass.
Our present findings indicate no adverse programming of body weight, adiposity, glucose tolerance, and metabolic flexibility by dietary (solid) fructose in comparison to glucose in the post-weaning diet in mice.
代谢编程不仅发生在围产期，还发生在断奶后。本研究旨在评估与葡萄糖相比，断奶后饮食中的果糖是否会影响成年后的体重、肥胖程度、葡萄糖耐量、代谢灵活性和健康。
3 周龄雄性和雌性 C57BL6/JRccHsd 小鼠接受 32 能量百分比（en%）葡萄糖或果糖的干预饮食，仅 3 周。然后，所有动物都转换为相同的 40 en%高脂肪饮食 9 周。在研究过程中的任何时间点，无论是雄性还是雌性，摄入葡萄糖或果糖饮食的动物的体重或肥胖程度均无显著差异。成年后的葡萄糖耐量不受断奶后饮食的影响，也不受间接测热法测量的活动、能量消耗和代谢灵活性的影响。在研究结束时，只有雌性的空腹血清胰岛素水平和 HOMA-IR 指数在断奶后果糖饮食中低于葡萄糖饮食（p=0.02），而胰腺β细胞质量没有差异。
与葡萄糖相比，本研究结果表明，在断奶后饮食中，饮食（固体）果糖不会对体重、肥胖程度、葡萄糖耐量和代谢灵活性产生不利的编程作用。
