White R, Lalouel J M
Sci Am. 1988 Feb;258(2):40-8. doi: 10.1038/scientificamerican0288-40.
New markers called RFLP's (for restriction-fragment length polymorphisms) can indicate the location on a chromosome of a disease-causing gene and serve to identify carriers. With enough markers one can map the human chromosomes--the first step toward an ambitious goal of molecular biology: sequencing the entire human genome.
一种名为RFLP(限制性片段长度多态性)的新标记能够指示致病基因在染色体上的位置,并用于识别携带者。有了足够多的标记,就可以绘制人类染色体图谱——这是朝着分子生物学的宏伟目标迈出的第一步:对整个人类基因组进行测序。