White R, Lalouel J M
Sci Am. 1988 Feb;258(2):40-8. doi: 10.1038/scientificamerican0288-40.
New markers called RFLP's (for restriction-fragment length polymorphisms) can indicate the location on a chromosome of a disease-causing gene and serve to identify carriers. With enough markers one can map the human chromosomes--the first step toward an ambitious goal of molecular biology: sequencing the entire human genome.