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Chromosome mapping with DNA markers.

作者信息

White R, Lalouel J M

出版信息

Sci Am. 1988 Feb;258(2):40-8. doi: 10.1038/scientificamerican0288-40.

Abstract

New markers called RFLP's (for restriction-fragment length polymorphisms) can indicate the location on a chromosome of a disease-causing gene and serve to identify carriers. With enough markers one can map the human chromosomes--the first step toward an ambitious goal of molecular biology: sequencing the entire human genome.

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