药物依赖的细胞和分子机制。
Cellular and molecular mechanisms of drug dependence.
作者信息
Koob G F, Bloom F E
机构信息
Research Institute of Scripps Clinic, La Jolla, CA 92037.
出版信息
Science. 1988 Nov 4;242(4879):715-23. doi: 10.1126/science.2903550.
PMID:2903550
Abstract
The molecular and cellular actions of three classes of abused drugs--opiates, psychostimulants, and ethanol--are reviewed in the context of behavioral studies of drug dependence. The immediate effects of drugs are compared to those observed after long-term exposure. A neurobiological basis for drug dependence is proposed from the linkage between the cellular and behavioral effects of these drugs.
摘要
在药物依赖行为研究的背景下，综述了三类滥用药物——阿片类药物、精神兴奋剂和乙醇——的分子和细胞作用。将药物的即时效应与长期接触后观察到的效应进行了比较。基于这些药物的细胞效应与行为效应之间的联系，提出了药物依赖的神经生物学基础。
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