Arillo A, Melodia F
Institute of Zoology, University of Genoa, Italy.
Toxicol Lett. 1988 Nov;44(1-2):71-6. doi: 10.1016/0378-4274(88)90131-2.
Trout liver mitochondria were incubated in the presence of micromolar concentration of potassium dichromate (Cr(VI)) under several experimental conditions. Cr(VI) strongly inhibited both state 3 and state 4 of respiration supplemented by NAD-linked substrates; it also slightly affected the respiration of FAD-linked substrates. Evidence is provided that the respiratory inhibition induced by dichromate is partially coupled to the Cr(VI) reduction mechanism occurring in mitochondria.
在几种实验条件下，将鳟鱼肝线粒体置于微摩尔浓度的重铬酸钾（Cr(VI)）存在的环境中进行孵育。Cr(VI)强烈抑制由NAD连接底物补充的呼吸状态3和状态4；它对FAD连接底物的呼吸也有轻微影响。有证据表明，重铬酸盐引起的呼吸抑制部分与线粒体中发生的Cr(VI)还原机制有关。
