苯乙烯及其他烷基苯衍生物对大鼠肝线粒体中与黄素腺嘌呤二核苷酸（FAD）和烟酰胺腺嘌呤二核苷酸（NAD）相关底物氧化的影响。

Effect of styrene and other alkyl benzene derivatives on oxidation of FAD- and NAD-linked substrates in rat liver mitochondria.

作者信息

Mickiewicz W, Rzeczycki W

机构信息

Department of General Chemistry, Medical Academy, Gdańsk, Poland.

出版信息

Biochem Pharmacol. 1988 Dec 1;37(23):4439-44. doi: 10.1016/0006-2952(88)90658-2.

DOI:10.1016/0006-2952(88)90658-2

PMID:2904817

Abstract

The effect on energetic metabolism of rat liver mitochondria (RLM) of styrene and other aliphatic benzene derivatives, i.e. toluene, ethylbenzene, alpha-methylstyrene and butylbenzene, is studied. It is shown that these compounds uncouple oxidative phosphorylation and this effect is connected with the stimulation of passive entry of protons into mitochondria. The relationship between hydrophobicity of these compounds and their biological activity and mechanism of uncoupling effect are discussed.

摘要

研究了苯乙烯及其他脂肪族苯衍生物，即甲苯、乙苯、α-甲基苯乙烯和丁苯对大鼠肝脏线粒体（RLM）能量代谢的影响。结果表明，这些化合物可使氧化磷酸化解偶联，且这种作用与质子被动进入线粒体的刺激有关。讨论了这些化合物的疏水性与其生物活性及解偶联作用机制之间的关系。