Mickiewicz W, Rzeczycki W
Department of General Chemistry, Medical Academy, Gdańsk, Poland.
Biochem Pharmacol. 1988 Dec 1;37(23):4439-44. doi: 10.1016/0006-2952(88)90658-2.
The effect on energetic metabolism of rat liver mitochondria (RLM) of styrene and other aliphatic benzene derivatives, i.e. toluene, ethylbenzene, alpha-methylstyrene and butylbenzene, is studied. It is shown that these compounds uncouple oxidative phosphorylation and this effect is connected with the stimulation of passive entry of protons into mitochondria. The relationship between hydrophobicity of these compounds and their biological activity and mechanism of uncoupling effect are discussed.
研究了苯乙烯及其他脂肪族苯衍生物，即甲苯、乙苯、α-甲基苯乙烯和丁苯对大鼠肝脏线粒体（RLM）能量代谢的影响。结果表明，这些化合物可使氧化磷酸化解偶联，且这种作用与质子被动进入线粒体的刺激有关。讨论了这些化合物的疏水性与其生物活性及解偶联作用机制之间的关系。
