甲状腺素诱导的大鼠肝脏线粒体泛醌变化。

Thyroxine-induced changes in rat liver mitochondrial ubiquinone.

作者信息

Horrum M A, Tobin R B, Ecklund R E

出版信息

Biochem Biophys Res Commun. 1986 Jul 16;138(1):381-6. doi: 10.1016/0006-291x(86)90292-5.

Abstract

Ubiquinone was extracted from liver mitochondria isolated from euthyroid and hyperthyroid rats. The redox state of ubiquinone was determined during States III and IV respiration with succinate or glutamate-malate substrates. Ubiquinone was more reduced during State III or IV in the hyperthyroid mitochondria with either substrate. Furthermore, the concentration of ubiquinone increased in the hyperthyroid rats.

摘要

从甲状腺功能正常和甲状腺功能亢进的大鼠分离出的肝线粒体中提取泛醌。在用琥珀酸或谷氨酸-苹果酸作为底物的呼吸状态III和IV期间测定泛醌的氧化还原状态。在使用任何一种底物时，甲状腺功能亢进的线粒体在呼吸状态III或IV期间泛醌的还原程度更高。此外，甲状腺功能亢进的大鼠体内泛醌的浓度增加。