Rheumatology Unit, Internal Medical Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Curr Opin Rheumatol. 2018 Jan;30(1):87-93. doi: 10.1097/BOR.0000000000000468.
The review gives an updated overview of some of the new concepts in the management of psoriatic arthritis (PsA): early diagnosis, remission as an objective, treat-to-target, and treatment guidelines.
Early diagnosis, targeting remission as part of a treatment strategy, and new guidelines providing evidence-based support to these concepts are main topics in recent publications.
Dermatologists and rheumatologists should work together to reduce the number of patients remaining undiagnosed, and the time to do so.Remission definition in PsA is still controversial. There is good evidence and convincing arguments for both multidimensional measures, such as minimal disease activity, or unidimensional ones, as disease activity index for PsA. New data on the analysis of tight control of inflammation in early PsA trial showed that the strategy might not be cost-effective on the short term, and that oligoarthritis is less benefited.The new European League Against Rheumatism and Group for Research and Assessment of Psoriasis and PsA recommendations exhibit differences. Methotrexate and tumor necrosis factor inhibitors are favored in European League Against Rheumatism guidelines, whereas other conventional synthetic disease-modifying antirheumatic drugs and biologics are equally positioned in Group for Research and Assessment of Psoriasis and PsA recommendations.
本文对银屑病关节炎(PsA)管理的一些新概念进行了综述,包括早期诊断、以缓解为目标、达标治疗和治疗指南。
早期诊断、将缓解作为治疗策略的一部分,以及为这些概念提供循证支持的新指南,是近期出版物的主要内容。
皮肤科医生和风湿病医生应共同努力,减少未被诊断的患者数量,以及缩短诊断所需的时间。PsA 缓解的定义仍存在争议。有充分的证据和令人信服的论据支持多维指标,如最小疾病活动度,或单维指标,如疾病活动指数作为 PsA 的指标。早期 PsA 试验中对炎症严格控制的分析新数据表明,该策略在短期内可能没有成本效益,而且寡关节炎获益较少。新的欧洲抗风湿病联盟和银屑病与银屑病关节炎研究评估组的建议存在差异。欧洲抗风湿病联盟指南推荐甲氨蝶呤和肿瘤坏死因子抑制剂,而银屑病与银屑病关节炎研究评估组的建议则认为其他传统合成改善病情抗风湿药物和生物制剂同样有效。