Patil Sarika J, Thorat Vandana M, Koparde Akshada A, Bhosale Rohit R, Chavan Dhanashri D, Tiwari Devkumar D
Department of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (KVV) Deemed to be University, Karad- 415539, Maharashtra, India.
Department of Pharmaceutical Chemistry, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (KVV) Deemed to be University, Karad- 415539, Maharashtra, India.
Pharm Nanotechnol. 2024 Mar 18. doi: 10.2174/0122117385293018240312050646.
Rheumatoid arthritis (RA) is a chronic condition causing joint pain and inflammation that has now spurred the interest in nanotechnology-based drug delivery for more effective treatment, and in this regard, carbon nanotubes (CNTs) are being explored for their potential to deliver the drugs steadily to manage the RA. Many investigators have been investigating both single-walled carbon nanotubes (SWCNT) as well as multi-walled carbon nanotubes (MWCNT) for managing arthritis via targeted drug delivery. Moreover, functionalized CNTs show promise in delivering the drugs precisely and in a controlled manner, thereby minimizing toxicity. However, research on applications of CNTs as drug carriers for RA remains limited, thus necessitating further exploration to address the various challenges. In this present piece of writing, challenges in RA treatment and the advances in applications of CNTs for RA management are reported, consequently reflecting the CNTs as advanced drug delivery vehicles for arthritis treatment.
类风湿性关节炎（RA）是一种导致关节疼痛和炎症的慢性疾病，目前已激发了人们对基于纳米技术的药物递送以实现更有效治疗的兴趣。在这方面，正在探索碳纳米管（CNT）将药物稳定递送来治疗RA的潜力。许多研究人员一直在研究单壁碳纳米管（SWCNT）和多壁碳纳米管（MWCNT），以通过靶向药物递送治疗关节炎。此外，功能化的碳纳米管在精确和可控地递送药物方面显示出前景，从而将毒性降至最低。然而，关于碳纳米管作为RA药物载体的应用研究仍然有限，因此有必要进一步探索以应对各种挑战。在本篇文章中，报告了RA治疗中的挑战以及碳纳米管在RA管理应用方面的进展，从而将碳纳米管视为用于关节炎治疗的先进药物递送载体。
