屋尘螨诱导的变应性鼻炎的变应原特异性皮下免疫疗法的长期疗效
Long-term effects of allergen-specific subcutaneous immunotherapy for house dust mite induced allergic rhinitis.
作者信息
Sahin E, Dizdar D, Dinc M E, Cirik A A
机构信息
Department of Otolaryngology, Head and Neck Surgery,Bayındır Hospital Icerenkoy,Istanbul,Turkey.
Department of Otorhinolaryngology,Medical Park Bahçelievler Hospital,Faculty of Medicine,Istanbul Kemerburgaz University,Istanbul,Turkey.
出版信息
J Laryngol Otol. 2017 Nov;131(11):997-1001. doi: 10.1017/S0022215117002110. Epub 2017 Oct 17.
BACKGROUND
Allergic rhinitis is strongly associated with the presence of house dust mites. This study investigated the long-term effects of allergen-specific immunotherapy. Allergen-specific immunotherapy was applied over three years. The study was based on a 10-year follow up of patients with allergic rhinitis.
METHODS
The study was conducted between 2001 and 2015. Skin prick test results and symptom scores were evaluated before (26 patients) and after 3 years (20 patients) of allergen-specific immunotherapy (using data from a previously published study), and 10 years after allergen-specific immunotherapy had ended (20 of 26 patients).
RESULTS
The symptom scores before allergen-specific immunotherapy were significantly higher than those obtained after 3 years of allergen-specific immunotherapy and 10 years after allergen-specific immunotherapy (p 0.0175).
CONCLUSION
Subcutaneous immunotherapy is an effective treatment for house dust mite induced allergic rhinitis.
背景
过敏性鼻炎与屋尘螨的存在密切相关。本研究调查了变应原特异性免疫疗法的长期效果。变应原特异性免疫疗法应用了三年。该研究基于对过敏性鼻炎患者的10年随访。
方法
该研究在2001年至2015年期间进行。在变应原特异性免疫疗法前（26例患者）、3年后（20例患者）（使用先前发表研究的数据）以及变应原特异性免疫疗法结束10年后（26例患者中的20例）评估皮肤点刺试验结果和症状评分。
结果
变应原特异性免疫疗法前的症状评分显著高于变应原特异性免疫疗法3年后和变应原特异性免疫疗法结束10年后的症状评分（p<0.0175）。
结论
皮下免疫疗法是治疗屋尘螨诱发过敏性鼻炎的有效方法。
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