Song Y, Long J, Wang T, Xie J, Wang M, Tan G
Department of Otolaryngology - Head Neck Surgery,Third Xiangya Hospital of Central South University,Changsha,Hunan,China.
Department of Otolaryngology - Head Neck Surgery,Hunan Children's Hospital,Changsha,China.
J Laryngol Otol. 2018 Mar;132(3):230-235. doi: 10.1017/S0022215117002547. Epub 2018 Jan 28.
To observe the five-year efficacy of standardised specific subcutaneous immunotherapy for house dust mite allergy in monosensitised and polysensitised children with persistent allergic rhinitis.
From January 2007 to August 2009, 236 children with persistent allergic rhinitis were divided into 2 groups: 1 group received standardised specific subcutaneous immunotherapy using house dust mite extract; the other received pharmacotherapy with intranasal corticosteroids and oral antihistamines. A total of 193 patients (106 in the immunotherapy group and 87 in the pharmacotherapy group) completed treatment. Scores for symptoms, total medication and quality of life were evaluated.
The subcutaneous immunotherapy group demonstrated a significant reduction in visual analogue scale scores, Rhinoconjunctivitis Quality of Life Questionnaire scores and total medication scores (p 0.05). No serious adverse events occurred.
Standardised subcutaneous immunotherapy has long-term efficacy for children with persistent allergic rhinitis. Single-allergen subcutaneous immunotherapy was appropriate for allergic rhinitis caused by multiple allergens, including house dust mites, in the paediatric population.
观察标准化特异性皮下免疫疗法对单致敏和多致敏持续性变应性鼻炎儿童尘螨过敏的五年疗效。
2007年1月至2009年8月，将236例持续性变应性鼻炎儿童分为2组：1组采用尘螨提取物进行标准化特异性皮下免疫疗法；另一组采用鼻用糖皮质激素和口服抗组胺药进行药物治疗。共有193例患者（免疫治疗组106例，药物治疗组87例）完成治疗。对症状、总用药量和生活质量评分进行评估。
皮下免疫治疗组视觉模拟量表评分、鼻结膜炎生活质量问卷评分和总用药量评分显著降低（p<0.05）。未发生严重不良事件。
标准化皮下免疫疗法对持续性变应性鼻炎儿童具有长期疗效。单过敏原皮下免疫疗法适用于儿科人群中由多种过敏原（包括尘螨）引起的变应性鼻炎。
