Salonen Laura M, Pinela Sara R, Fernandes Soraia P S, Louçano João, Carbó-Argibay Enrique, Sarriá Marisa P, Rodríguez-Abreu Carlos, Peixoto João, Espiña Begoña
International Iberian Nanotechnology Laboratory (INL), Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal.
International Iberian Nanotechnology Laboratory (INL), Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal; CEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal.
J Chromatogr A. 2017 Nov 24;1525:17-22. doi: 10.1016/j.chroma.2017.10.017. Epub 2017 Oct 6.
Phycotoxins, compounds produced by some marine microalgal species, can reach high concentrations in the sea when a massive proliferation occurs, the so-called harmful algal bloom. These compounds are especially dangerous to human health when concentrated in the digestive glands of seafood. In order to generate an early warning system to alert for approaching toxic outbreaks, it is very important to improve monitoring methods of phycotoxins in aquatic ecosystems. Solid-phase adsorption toxin tracking devices reported thus far based on polymeric resins have not been able to provide an efficient harmful algal bloom prediction system due to their low adsorption capabilities. In this work, a water-stable covalent organic framework (COF) was evaluated as adsorbent for the hydrophobic toxin okadaic acid, one of the most relevant marine toxins and the parental compound of the most common group of toxins responsible for the diarrhetic shellfish poisoning. Adsorption kinetics of okadaic acid onto the COF in seawater showed that equilibrium concentration was reached in only 60min, with a maximum experimental adsorption of 61mgg. Desorption of okadaic acid from the COF was successful with both 70% ethanol and acetonitrile as solvent, and the COF material could be reused with minor losses in adsorption capacity for three cycles. The results demonstrate that COF materials are promising candidates for solid-phase adsorption in water monitoring devices.
藻毒素是由一些海洋微藻物种产生的化合物，当大规模繁殖（即所谓的有害藻华）发生时，它们在海洋中的浓度会达到很高。当这些化合物在海鲜的消化腺中浓缩时，对人类健康尤其危险。为了建立一个早期预警系统以警示即将到来的有毒藻华爆发，改进水生生态系统中藻毒素的监测方法非常重要。迄今为止报道的基于聚合树脂的固相吸附毒素跟踪装置，由于其低吸附能力，未能提供一个有效的有害藻华预测系统。在这项工作中，评估了一种水稳定的共价有机框架（COF）作为疏水性毒素冈田酸的吸附剂，冈田酸是最相关的海洋毒素之一，也是导致腹泻性贝类中毒的最常见毒素组的母体化合物。冈田酸在海水中对COF的吸附动力学表明，仅在60分钟内就达到了平衡浓度，最大实验吸附量为61mg/g。以70%乙醇和乙腈作为溶剂，冈田酸从COF上的解吸成功，并且COF材料可以重复使用三个循环，吸附容量仅有轻微损失。结果表明，COF材料是水监测装置中固相吸附的有前途的候选材料。
