Institute of Physiology, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; Neurology Department, Centro Hospitalar do Baixo Vouga - Aveiro, Av. Artur Ravara, 3814-501 Aveiro, Portugal.
Institute of Physiology, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Front Neuroendocrinol. 2019 Jan;52:1-11. doi: 10.1016/j.yfrne.2017.10.002. Epub 2017 Oct 13.
Obesity has been consistently associated with Alzheimer's disease (AD) though the exact mechanisms by which it influences cognition are still elusive and subject of current research. Adiponectin, the most abundant adipokine in circulation, is inversely correlated with adipose tissue dysfunction and seems to be a central player in this association. In fact, different signalling pathways are shared by adiponectin and proteins involved in AD pathophysiology and considerable amount of evidence supports its direct and indirect influence on β-amyloid and tau aggregates formation. In this paper we present a critical review of cellular, animal and clinical studies which have contributed to a more thorough understanding of the extent to which adiponectin influences the risk of developing AD as well as its progression. Finally, the effect of acetylcholinesterase inhibitors on circulating adiponectin levels, possible therapeutic applications and future research strategies are also discussed.
肥胖症与阿尔茨海默病（AD）密切相关，尽管其影响认知的确切机制仍难以捉摸，也是当前研究的主题。脂联素是循环中最丰富的脂肪因子，与脂肪组织功能障碍呈负相关，似乎是这种关联的核心参与者。事实上，脂联素和参与 AD 病理生理学的蛋白质共享不同的信号通路，大量证据支持其对β-淀粉样蛋白和 tau 聚集物形成的直接和间接影响。本文对细胞、动物和临床研究进行了批判性回顾，这些研究有助于更深入地了解脂联素对 AD 发病风险及其进展的影响程度。最后，还讨论了乙酰胆碱酯酶抑制剂对循环脂联素水平的影响、可能的治疗应用和未来的研究策略。
