Moskowitz H, Burns M
Southern California Research Institute, Los Angeles 90066.
Cutis. 1988 Oct 27;42(4A):14-8.
The behavioral effects of the antihistamines terfenadine and diphenhydramine were compared in a placebo-controlled, double-blind crossover study. Performance of skills deemed important in safe man-machine interactions was objectively assessed one, three, and five hours after administration of test substances. The results indicate that diphenhydramine use resulted in various degrees of impairment of the ability to perform a visual-search task, a tracking task, a divided-attention task, and a vigilance task. Terfenadine users performed as well as or better than placebo-treated subjects. No differences between terfenadine and placebo were found on a subjective evaluation scale. Diphenhydramine users consistently reported feelings of impairment.
在一项安慰剂对照、双盲交叉研究中，对抗组胺药特非那定和苯海拉明的行为效应进行了比较。在给予受试药物1小时、3小时和5小时后，对在安全人机交互中被认为重要的技能表现进行了客观评估。结果表明，使用苯海拉明会导致执行视觉搜索任务、跟踪任务、分散注意力任务和警觉任务的能力出现不同程度的损害。使用特非那定的受试者表现与接受安慰剂治疗的受试者相当或更好。在主观评估量表上，未发现特非那定与安慰剂之间存在差异。使用苯海拉明的受试者一直报告有受损的感觉。
