抗组胺药苯海拉明和特非那定（RMI 9918）对中枢神经系统的作用。
CNS effects of the antihistamines diphenhydramine and terfenadine (RMI 9918).
作者信息
Fink M, Irwin P
出版信息
Pharmakopsychiatr Neuropsychopharmakol. 1979 Jan;12(1):35-44. doi: 10.1055/s-0028-1094592.
PMID:33398
Abstract
The quantitative EEG profile of a putative antihistaminic drug, terfenadine, was determined in a crossover comparison with diphenhydramine in normal male volunteers. Terfenadine failed to elicit the characteristic EEG or behavioral effects of sedative antihistaminics, and was distinguishable from diphenhydramine. The EEG profile confirmed the lack of CNS effect observed in preclinical and clinical trials.
摘要
在正常男性志愿者中，通过与苯海拉明进行交叉比较，测定了一种假定的抗组胺药物特非那定的定量脑电图特征。特非那定未能引发镇静性抗组胺药的典型脑电图或行为效应，且与苯海拉明有明显区别。脑电图特征证实了在临床前和临床试验中观察到的中枢神经系统无效应。
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