Auestad N, Korsak R A, Morrow J W, West D B, Bergstrom J D, Edmond J
Division of Nutritional Sciences, UCLA School of Public Health.
FASEB J. 1988 Dec;2(15):3108-12. doi: 10.1096/fasebj.2.15.2903839.
We examined the effect of a lower dietary cholesterol load on hepatic lipogenic capacity and plasma cholesterol concentrations during the normal suckling period in artificially reared preweanling rats. The artificially reared rats were fed a milk formula that contained low or normal concentrations of cholesterol during the period from the 5th to 17th day after birth. The activities of HMG-CoA synthase and HMG-CoA reductase in livers of 17-day-old rat pups reared on the low-cholesterol diet were enhanced three- to five-fold over those observed in the age-matched rats in the normal cholesterol and mother-reared control groups. The concentration of cholesterol in plasma of rats reared on the low-cholesterol milk was about 20% lower than that for mother-reared controls. In contrast, rats reared on milk with normal cholesterol content exhibited plasma cholesterol levels about 25 and 50% higher than the mother-reared and low cholesterol groups, respectively. The long-term metabolic consequences of rearing rats on milk formulations without adequate cholesterol remains to be determined.
我们研究了在人工饲养的断奶前大鼠正常哺乳期，降低饮食中胆固醇负荷对肝脏脂肪生成能力和血浆胆固醇浓度的影响。在出生后第5天至第17天期间，给人工饲养的大鼠喂食含有低胆固醇或正常胆固醇浓度的奶粉。与正常胆固醇饮食组和由母鼠饲养的对照组中年龄匹配的大鼠相比，食用低胆固醇饮食饲养的17日龄幼鼠肝脏中HMG-CoA合酶和HMG-CoA还原酶的活性增强了三到五倍。食用低胆固醇奶粉饲养的大鼠血浆胆固醇浓度比由母鼠饲养的对照组低约20%。相比之下，食用正常胆固醇含量奶粉饲养的大鼠血浆胆固醇水平分别比由母鼠饲养的组和低胆固醇组高约25%和50%。用不含足够胆固醇的奶粉饲养大鼠的长期代谢后果仍有待确定。
