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哺乳期大鼠肝脏3-羟基-3-甲基戊二酰辅酶A还原酶对窝仔数的反应。

Hepatic 3-hydroxy-3-methyl-glutaryl-CoA reductase response to litter size in suckling rats.

作者信息

Hahn P, Walker B L

出版信息

Can J Biochem. 1979 Oct;57(10):1216-9. doi: 10.1139/o79-159.

DOI:10.1139/o79-159
PMID:396009
Abstract

Rats were raised in litters of 3 or 14 from the 3rd postnatal day. Already, 2 days later on day 5, those raised in groups of three had elevated blood cholesterol and insulin levels and a very much lower hepatic 3-hydroxy-3-methyl-glutaryl-CoA (HMG) CoA) reductase activity, than the other group. When aged 40 days, hepatic HMG CoA reductase activity was higher in the group raised three rats per litter than in the large litter group.

摘要

从出生后第3天起，将大鼠按每窝3只或14只饲养。在出生后第5天，也就是2天后，每窝3只饲养的大鼠的血液胆固醇和胰岛素水平升高，肝脏3-羟基-3-甲基戊二酰辅酶A（HMG CoA）还原酶活性比另一组低得多。40日龄时，每窝饲养3只大鼠的组中肝脏HMG CoA还原酶活性高于大窝组。

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