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Lack of dose-rate effect for mutation induction by gamma-rays in human TK6 cells.

作者信息

König F, Kiefer J

机构信息

Strahlenzentrum der Justus Liebig Universität, Giessen, F.R. Germany.

出版信息

Int J Radiat Biol. 1988 Dec;54(6):891-7. doi: 10.1080/09553008814552301.

DOI:10.1080/09553008814552301
PMID:2903887
Abstract

Survival and mutation induction in a human lymphoblastoid cell line ('TK6'), after acute X- and low dose rate continuous gamma-irradiation, were investigated using the hypoxanthine guanine phosphoribosyl transferase (HGPRT)- and the thymidine kinase (TK)-mutation assay. The surviving fraction after acute exposure decreased exponentially (D0 = 0.47 Gy). The HGPRT- and TK-mutation frequencies after acute X- and continuous gamma-irradiation (2.7 and 27 mGy/h) showed linear responses and no dose-rate dependence.

摘要

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