Guan Bingsheng, Chen YanYa, Yang Jingge, Yang Wah, Wang Cunchuan
Department of Gastrointestinal Surgery, First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Department of Nursing Science, School of Medicine, Jinan University, Guangzhou, 510630, China.
Obes Surg. 2017 Dec;27(12):3292-3305. doi: 10.1007/s11695-017-2965-2.
We aimed to make a meta-analysis regarding the effect of bariatric surgery on thyroid function in obese patients. PubMed, EMBASE, CENTRAL, and four Chinese databases were searched for clinical studies. Data were pooled using Review Manager 5.3, and subgroup and sensitivity analyses were performed if necessary and feasible. As a result, 24 articles were included into meta-analysis. Bariatric surgery was associated with significant decrease in TSH, FT3, and T3 levels. However, FT4, T4, and rT3 levels were not significantly changed postoperatively. In addition, bariatric surgery had a favorable effect on overt and subclinical hypothyroid, with reduction of thyroid hormone requirements postoperatively. In conclusion, TSH, FT3, and T3 decrease are expected following bariatric surgery, as well as non-significant change of T4, FT4, and rT3 levels.
我们旨在对肥胖患者进行减肥手术对甲状腺功能的影响进行荟萃分析。检索了PubMed、EMBASE、CENTRAL和四个中文数据库中的临床研究。使用Review Manager 5.3对数据进行汇总，必要且可行时进行亚组分析和敏感性分析。结果，24篇文章被纳入荟萃分析。减肥手术与促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）和三碘甲状腺原氨酸（T3）水平显著降低相关。然而，术后游离甲状腺素（FT4）、甲状腺素（T4）和反三碘甲状腺原氨酸（rT3）水平无显著变化。此外，减肥手术对显性和亚临床甲状腺功能减退有良好效果，术后甲状腺激素需求量减少。总之，减肥手术后预计TSH、FT3和T3会降低，T4、FT4和rT3水平无显著变化。
