Fu Yanling, Zhu Yimin
Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 May 25;46(3):328-333. doi: 10.3785/j.issn.1008-9292.2017.06.17.
Gonadotropin-releasing hormone (GnRH) plays an important role in the process of reproduction. Studies have shown that a family of peptides Kisspeptin can act on GnRH-related neurons, stimulating the secretion of GnRH, and activating the hypothalamic-pituitary-gonadal axis. Both animal experiments and clinical studies have shown that exogenous administration of Kisspeptin is able to induce physiological GnRH release in healthy individuals and those with endocrine-disorders, which brings great hope for treatment of reproductive endocrine diseases. The effect of Kisspeptin is similar to the physiological process in induction of ovulation and ovum maturation, leading to high security and efficiency for women receiving fertilization. Kisspeptin is involved in trophoblast invasion, so it may be useful for predicting pregnancy outcomes. In addition, Kisspeptin is the key hormone in the onset of puberty acting as a signal transducer in metabolism and reproduction, so it provides some directions for studies of polycystic ovary syndrome, hyperprolactinemia, and other metabolic-related reproductive endocrine diseases. This article reviews the character of Kisspeptin and the prospect of its application in treatment of reproductive endocrine diseases.
促性腺激素释放激素（GnRH）在生殖过程中发挥着重要作用。研究表明，一类名为 kisspeptin 的肽能作用于 GnRH 相关神经元，刺激 GnRH 的分泌，并激活下丘脑 - 垂体 - 性腺轴。动物实验和临床研究均显示，外源性给予 kisspeptin 能够在健康个体以及内分泌紊乱个体中诱导生理性 GnRH 释放，这为生殖内分泌疾病的治疗带来了巨大希望。Kisspeptin 在诱导排卵和卵子成熟方面的作用类似于生理过程，对于接受受精的女性而言具有很高的安全性和有效性。Kisspeptin 参与滋养层细胞侵袭，因此可能有助于预测妊娠结局。此外，Kisspeptin 是青春期启动的关键激素，在代谢和生殖中充当信号转导器，所以它为多囊卵巢综合征、高催乳素血症及其他代谢相关生殖内分泌疾病的研究提供了一些方向。本文综述了 kisspeptin 的特性及其在生殖内分泌疾病治疗中的应用前景。
